INT170552

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.97
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
neuron 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 1 84.08 Quite High
imagery 6 57.60 Quite High
anesthesia 40 5.00 Very Low Very Low Very Low
ketamine 16 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 338 99.96 Very High Very High Very High
Glaucoma 34 86.20 High High
Sprains And Strains 174 81.12 Quite High
Hypopigmentation 8 74.80 Quite High
Congenital Anomalies 2 57.36 Quite High
Obesity 34 7.36 Low Low
Diabetes Mellitus 40 6.96 Low Low
Aging 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our experiments show that a genetic deficiency of CAII in mice homozygous for a mutation in the Car2 gene does not alter IOP.
Neg (not) Regulation (alter) of Negative_regulation (deficiency) of CAII associated with ocular hypertension
1) Confidence 0.39 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.96 Pain Relevance 0
It also is possible that CAII substantially contributes to aqueous humor secretion but that functional mouse CAIV is sufficient to prevent an effect of CAII deficiency on IOP in Car2 mutant mice.
Regulation (effect) of Negative_regulation (deficiency) of CAII associated with ocular hypertension
2) Confidence 0.27 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.01 Pain Relevance 0
We therefore tested if NM, by blocking TRPM7 currents, could affect neuron excitation upon reducing Ca2+.
Regulation (affect) of Negative_regulation (reducing) of Ca2 in neuron
3) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.07

General Comments

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