INT170553

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Context Info
Confidence 0.05
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 16.19
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Narf) biological_process (Narf)
Anatomy Link Frequency
outflow 1
Narf (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 226 99.98 Very High Very High Very High
ketamine 88 99.34 Very High Very High Very High
depression 22 94.88 High High
alcohol 11 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 2030 100.00 Very High Very High Very High
Aging 33 99.70 Very High Very High Very High
Sprains And Strains 963 99.64 Very High Very High Very High
Glaucoma 349 99.64 Very High Very High Very High
Depression 11 94.88 High High
Hypotension 22 93.48 High High
Unconsciousness 11 90.16 High High
Cardiovascular Disorder Under Development 11 85.04 High High
Obesity 187 76.00 Quite High
Diabetes Mellitus 220 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, intraperitoneally administered ketamine (100 mg/kg) was shown to rapidly decrease IOP in a different rat study [36].
Negative_regulation (decrease) of IOP associated with ketamine and ocular hypertension
1) Confidence 0.05 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.81 Pain Relevance 0.55
Thus, although both rat and mouse studies show that anesthesia decreases IOP, the studies do not agree on the timing of the effect.
Negative_regulation (decreases) of IOP associated with anesthesia and ocular hypertension
2) Confidence 0.05 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.91 Pain Relevance 0.92
The greater the dose the greater the decrease in IOP.
Negative_regulation (decrease) of IOP associated with ocular hypertension
3) Confidence 0.05 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.44 Pain Relevance 0.38
IOP decreased further by the next reading (at 5 minutes) after which it remained stable for the duration of the experiment (20 minutes)[36].
Negative_regulation (decreased) of IOP associated with ocular hypertension
4) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.94 Pain Relevance 0.71
IOP decreased significantly between a conscious measurement and the first possible measurement under anesthesia (defined as time 0).
Negative_regulation (decreased) of IOP associated with anesthesia and ocular hypertension
5) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.85 Pain Relevance 0.61
Gender does not typically affect IOP and aging results in an IOP decrease in some strains.
Negative_regulation (decrease) of IOP associated with aging, sprains and strains and ocular hypertension
6) Confidence 0.04 Published 2001 Journal BMC Genet Section Abstract Doc Link PMC48141 Disease Relevance 1.87 Pain Relevance 0
IOP was slightly decreased at both 12 months (12.2 ± 0.2 mmHg) and 19 months (12.2 ± 0.3 mmHg) compared to 3 months (13.1 ± 0.3 mmHg) and 7 months (13.3 ± 0.3 mmHg).
Negative_regulation (decreased) of IOP associated with ocular hypertension
7) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.20 Pain Relevance 0
For all doses, IOP decreased by 25 minutes (P = 0.005 for time).
Negative_regulation (decreased) of IOP associated with ocular hypertension
8) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.47 Pain Relevance 0.38
Decreasing IOP correlates with increasing age in the human Japanese population [50,51].
Negative_regulation (Decreasing) of IOP associated with ocular hypertension
9) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.69 Pain Relevance 0.09
IOP was even lower in the 24 month B6 mice (10.8 ± 0.4 mmHg), and again the average IOP of young controls measured at the same time was not changed (13.5 ± 0.2, n = 12).
Negative_regulation (lower) of IOP associated with ocular hypertension
10) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.16 Pain Relevance 0
Ketamine usually appears to increase IOP [31-33], but there are reports of ketamine having no effect on IOP or even reducing IOP [31,34].
Negative_regulation (reducing) of IOP associated with ketamine and ocular hypertension
11) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.37 Pain Relevance 0.14
mice, while it lowered the IOP significantly in age-matched wild-type mice (Figure S4C).


Negative_regulation (lowered) of IOP associated with ocular hypertension
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.55 Pain Relevance 0
In addition, ocular hypotensives commonly used to treat human glaucoma show efficacy in lowering IOP in this model.
Negative_regulation (lowering) of IOP associated with glaucoma and ocular hypertension
13) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 1.04 Pain Relevance 0
While progressive angle closure may be the etiology prior to elevated IOP in mice lacking Vav2 and Vav3 function, it may alternatively be a subsequent change related to other alterations in angle structures which might also affect aqueous humor outflow.
Negative_regulation (lacking) of IOP in outflow associated with ocular hypertension
14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.89 Pain Relevance 0

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