INT170554

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Context Info
Confidence 0.17
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 12.36
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp)
Anatomy Link Frequency
white matter 1
Renbp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 15 97.64 Very High Very High Very High
Kinase C 25 97.28 Very High Very High Very High
cytokine 55 89.12 High High
ischemia 98 84.72 Quite High
Inflammation 155 84.64 Quite High
rheumatoid arthritis 9 54.56 Quite High
fibrosis 15 51.12 Quite High
diabetic neuropathy 12 35.12 Quite Low
imagery 102 31.68 Quite Low
Glutamate 203 8.80 Low Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 176 100.00 Very High Very High Very High
Myeloid Leukemia 58 99.60 Very High Very High Very High
Hyperlipidemia 22 99.46 Very High Very High Very High
Sprains And Strains 89 98.96 Very High Very High Very High
Diabetes Mellitus 338 98.74 Very High Very High Very High
Lung Cancer 14 98.68 Very High Very High Very High
Hyperinsulinism 4 98.66 Very High Very High Very High
Increased Venous Pressure Under Development 71 98.16 Very High Very High Very High
Hypertension 20 97.90 Very High Very High Very High
Diabetic Angiopathy 9 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between Orientation and Age was also significant, F(3,111)?
Age Binding (interaction) of
1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0 Pain Relevance 0
The interaction between Orientation and Age was also significant, F(3,111)?
Age Binding (interaction) of
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0 Pain Relevance 0
The interaction between Orientation and Age was also significant, F(3,111)?
Age Binding (interaction) of
3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0 Pain Relevance 0
Here too, the effect of Hand, F(1,37)<1, and the Hand × Age interaction, F(1,37)<1, were not significant, indicating that participants of both groups did not favor their dominant hand.


Age Binding (interaction) of
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0 Pain Relevance 0
Average IOP for age matched mice of the same strain assessed at different times typically differed by no more than 1.5 mmHg, and the differences were usually smaller.
age Binding (Average) of associated with sprains and strains and ocular hypertension
5) Confidence 0.07 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.06 Pain Relevance 0
A major way in which AGEs exert their cellular effects is by ligation of the multiligand receptor for AGE (RAGE) (10–13).
AGE Binding (ligation) of
6) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.09 Pain Relevance 0.16
There are strong additional interactions with other risk factors, such as hypertension, hyperglycaemia and hyperinsulinaemia, hypercholesterolaemia, hyperlipidaemia, endothelial dysfunction, AGE formation and the ApoE4 genotype.
AGE Binding (formation) of associated with hypertension, hyperinsulinism and hyperlipidemia
7) Confidence 0.03 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.57 Pain Relevance 0
Furthermore, blocking AGE-RAGE interactions leads to diminished cell growth [186].
AGE Binding (interactions) of
8) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.37 Pain Relevance 0.05
Nitric Oxide donors can scavenge free radicals and inhibit AGE formation [163].
AGE Binding (formation) of
9) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.51 Pain Relevance 0
close to AGE, where normal
AGE Binding (close) of
10) Confidence 0.02 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.70 Pain Relevance 0.04
Furthermore, the formation of AGE, such as CML and pentosidine, is accelerated in regions of oxidative stress.
AGE Binding (formation) of associated with stress and myeloid leukemia
11) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 1.57 Pain Relevance 0.09
Recently, a novel therapeutic strategy has been to attack the AGE crosslinks formed in biological systems.
AGE Binding (crosslinks) of
12) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.44 Pain Relevance 0
AGE receptor binding can initiate important signalling pathways involving activation of protein kinase C [108, 165], tyrosine phosphorylation of Janus kinase (JAK)/signal transducers and activators of transcription (STAT) [66], recruitment of phosphotidylinositol 3' kinase to Ras, [30] and induction of oxidative stress cascades which lead toNF?
AGE Binding (binding) of associated with stress and kinase c
13) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.60 Pain Relevance 0.10
Here, it is also unclear why many diabetic damages leave the glia cells of the brain unaffected (despite AGE and lipid peroxide formation) for a long time whereas in certain forms of arteriosclerosis the glial cells become “aggressive” and attack the nerve cells and axons with ROS (e.g. as in “white matter lesions” of the brain).
AGE Binding (formation) of in white matter associated with diabetes mellitus and increased venous pressure under development
14) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 1.26 Pain Relevance 0
To date there have been a range of approaches which seek to either prevent AGE formation, reduceAGE effects on cells, or even break established AGE crosslinks.
AGE Binding (crosslinks) of
15) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.44 Pain Relevance 0
An important pharmacological strategy for the inhibition of this process utilises the small nucleophilic hydrazine compound aminoguanidine, which is a potent inhibitor of AGE mediated crosslinking [15].
AGE Binding (crosslinking) of
16) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.30 Pain Relevance 0
To date there have been a range of approaches which seek to either prevent AGE formation, reduceAGE effects on cells, or even break established AGE crosslinks.
AGE Binding (formation) of
17) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.45 Pain Relevance 0

General Comments

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