INT170557

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 17.26
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lepr) extracellular space (Lepr) extracellular region (Lepr)
plasma membrane (Lepr)
Anatomy Link Frequency
body 2
hypothalamus 1
arcuate nucleus 1
skeletal muscle tissue 1
vessels 1
Lepr (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 189 99.96 Very High Very High Very High
Inflammation 166 99.18 Very High Very High Very High
vagus nerve 49 96.76 Very High Very High Very High
parabrachial 7 95.76 Very High Very High Very High
cytokine 104 95.24 Very High Very High Very High
Locus ceruleus 14 92.64 High High
amygdala 56 83.96 Quite High
Action potential 28 82.84 Quite High
Thalamus 14 67.56 Quite High
Cholecystokinin 56 67.52 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 524 100.00 Very High Very High Very High
Calcification 93 100.00 Very High Very High Very High
Body Weight 176 99.58 Very High Very High Very High
INFLAMMATION 170 99.18 Very High Very High Very High
Obesity 714 98.80 Very High Very High Very High
Ocular Hypertension 338 97.58 Very High Very High Very High
Infection 30 96.52 Very High Very High Very High
Influenza Virus Infection 54 95.80 Very High Very High Very High
Glaucoma 34 91.40 High High
Hyperglycemia 6 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test if genetic perturbations that cause obesity and diabetes can alter IOP, we compared groups of mice that were genetically similar except that they were either homozygous or heterozygous for a leptin receptor mutation (db) that results in early onset obesity and diabetes.
Gene_expression (mutation) of leptin receptor associated with diabetes mellitus, obesity and ocular hypertension
1) Confidence 0.67 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.93 Pain Relevance 0
Fenofibrate seems to differentially affect body weight and adiposity among OVX and Sham mice by a mechanism other than the modulation of leptin gene expression.
Gene_expression (expression) of leptin gene in body associated with body weight
2) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.41 Pain Relevance 0
Consistent with this finding, Guerre-Millo et al. [10] reported that serum leptin concentrations positively correlated with body weight and epididymal adipose tissue mass in fenofibrate-treated male mice [10], suggesting that fenofibrate modulates body weight, not by influencing leptin gene expression and food intake, but by enhancing energy expenditure [91, 92].
Gene_expression (expression) of leptin gene in body associated with body weight and obesity
3) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.01 Pain Relevance 0
LEPRB is also expressed in many other hypothalamic nuclei that may have a role in appetite.
Gene_expression (expressed) of LEPRB
4) Confidence 0.65 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0 Pain Relevance 0
POMC neurones in the arcuate nucleus, which express LEPRB, are activated by leptin.
Gene_expression (express) of LEPRB in arcuate nucleus
5) Confidence 0.65 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0 Pain Relevance 0
To test if genetic perturbations that cause obesity and diabetes can alter IOP, we compared groups of mice that were genetically similar except that they were either homozygous or heterozygous for a leptin receptor mutation (db) that results in early onset obesity and diabetes.
Gene_expression (mutation) of db associated with diabetes mellitus, obesity and ocular hypertension
6) Confidence 0.58 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.92 Pain Relevance 0
Both the POMC/CART and NPY/AgRP pathways express LEPRB and project to the leptin-dependent regions in the DMH, PVN and lateral hypothalamus (Table 1).
Gene_expression (express) of LEPRB in hypothalamus
7) Confidence 0.56 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.03
LEPRB is found in several brainstem nuclei involved in the control of food intake, such as the DMX, area postrema, NTS, parabrachial, hypoglossal, trigeminal, lateral reticular and cochlear nuclei, locus coeruleus and inferior olive [94].
Gene_expression (found) of LEPRB in inferior olive associated with medulla, locus ceruleus, vagus nerve and parabrachial
8) Confidence 0.56 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.92
The DMH is an important leptin target, as it expresses both leprb mRNA and protein [18,19].
Gene_expression (expresses) of leprb
9) Confidence 0.50 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.17 Pain Relevance 0.18
The PVN expresses LEPRB and is thus responsive to leptin [18,19].
Gene_expression (expresses) of LEPRB
10) Confidence 0.44 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.28 Pain Relevance 0.08
LEPRB is found in several brainstem nuclei involved in the control of food intake, such as the DMX, area postrema, NTS, parabrachial, hypoglossal, trigeminal, lateral reticular and cochlear nuclei, locus coeruleus and inferior olive [94].
Gene_expression (found) of LEPRB in locus coeruleus associated with medulla, locus ceruleus, vagus nerve and parabrachial
11) Confidence 0.19 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.92
As a dominant public TCR that recognizes PR8-NP366/Db epitope has been functionally expressed in the form of a stable transfectant [36], this allowed us to dissect to what extent the public TCR can cross-react to the naturally occurring NP366/Db variants identified from the bank of NP sequences (Table 1).
Gene_expression (expressed) of Db
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868023 Disease Relevance 0.57 Pain Relevance 0
Although we did not maintain our own colony of NOD mice, a colony kept by a collaborating laboratory (PLK) in the same animal suite has a spontaneous diabetes incidence of 80–90% in females by 30 weeks of age [56] indicating an animal environment that is conducive for diabetes development.


Gene_expression (development) of diabetes associated with diabetes mellitus
13) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 1.24 Pain Relevance 0.03
While Th2 shifts have occasionally been associated with diabetes protection, it is not clear that this shift is a part of the true protective mechanism in many cases [54].
Gene_expression (protection) of diabetes associated with diabetes mellitus
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 0.88 Pain Relevance 0.29
Thus, a nuclear import inhibitor extinguished autoimmune inflammation-driven islet loss and prevented further progression of diabetes thereby obviating the need for insulin replacement therapy.
Gene_expression (progression) of diabetes associated with inflammation and diabetes mellitus
15) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 1.43 Pain Relevance 0.23
To understand the mechanism that berberine regulates glucose and lipids, we performed RT2 PCR diabetes superarray to analyze the expression of diabetes-related genes in skeletal muscle tissue of KKAy mice.
Spec (analyze) Gene_expression (expression) of diabetes-related in skeletal muscle tissue associated with diabetes mellitus
16) Confidence 0.01 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.74 Pain Relevance 0
In vessels from patients with diabetes, MGP levels are lower than in normal vessels, which suggest that reduced MGP in diabetes may predispose to calcification [24].
Gene_expression (levels) of diabetes in vessels associated with calcification and diabetes mellitus
17) Confidence 0.01 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 3.07 Pain Relevance 0.10

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