INT170592

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Context Info
Confidence 0.17
First Reported 2001
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
CD86 4
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 68 85.56 High High
Inflammation 103 50.00 Quite Low
chemokine 56 5.00 Very Low Very Low Very Low
Inflammatory response 28 5.00 Very Low Very Low Very Low
Inflammatory mediators 18 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Etanercept 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 149 50.00 Quite Low
Infection 90 5.00 Very Low Very Low Very Low
Peritonitis 45 5.00 Very Low Very Low Very Low
Renal Failure 39 5.00 Very Low Very Low Very Low
Bacterial Infection 21 5.00 Very Low Very Low Very Low
Cancer 14 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low
Necrosis 8 5.00 Very Low Very Low Very Low
Cadaver 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this setting, HMB-PP-stimulated but not unstimulated co-cultures produced soluble factors that crossed the separating membrane and down-modulated CD14 as well as induced expression of CD40, CD86, and HLA-DR.
Neg (not) Regulation (modulated) of Gene_expression (expression) of CD40 in CD86
1) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.04
receptor (sTNFR) reversed the effects on CD14 and CD40 expression in transwell cultures (Fig.
Regulation (effects) of Gene_expression (expression) of CD40
2) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.04
B1 p50 oligonucleotides did not affect the expression of ICAM-1 in HUVEC, no matter whether added individually or simultaneously.


Neg (not) Spec (whether) Regulation (affect) of Gene_expression (oligonucleotides) of p50
3) Confidence 0.12 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
M CpG DNA, and CpG control DNA (target TLR9) and the activities of the p60 and p50 subunits of NF?
Regulation (activities) of Gene_expression (subunits) of p50
4) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
g/ml, were not effective in stimulating either p50 or p65 activities in either cell type.
Regulation (stimulating) of Gene_expression (activities) of p50
5) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
also appeared to be the major regulators of cell surface CD14, CD40, and CD86 expression, whereas GM-CSF and IL-4 had only minor effects (Fig. 4B).
Regulation (regulators) of Gene_expression (expression) of CD40 in CD86
6) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.03

General Comments

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