INT170596

Context Info Confidence 0.41 First Reported 2001 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.39 Pain Relevance 0.25

cytosol (RELA) nucleoplasm (RELA) aging (RELA) nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)

RELA (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 118 93.48 aspirin 51 82.56 dexamethasone 6 69.76 cytokine 18 53.96 Inflammatory response 17 21.52 chemokine 1 5.28 cINOD 7 5.00 Inflammatory stimuli 4 5.00 Arthritis 4 5.00 rheumatoid arthritis 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 141 93.48 Stress 2 62.20 Death 11 51.60 Malignant Neoplastic Disease 3 51.16 Injury 6 47.96 Diffuse Large B-cell Lymphoma 1 7.92 Cancer 19 5.00 Lymphatic System Cancer 12 5.00 Adhesions 10 5.00 Atherosclerosis 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the study presented we added antisense RelA p65 and NF-?

Regulation (antisense) of RelA

1) Confidence 0.41 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0.11

Immunofluorescence for the p65 subunit was used to visualise the translocation of NF-?

Regulation (Immunofluorescence) of p65

2) Confidence 0.17 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0 Pain Relevance 0

However, there are several time lag regulations in IL8 and its regulators, such as SOX9, MEF2A, NFIL3, ELK1, FOXF1, FOXD1, GATA2, FOXI1, REL and RELA.

Regulation (regulations) of RELA

3) Confidence 0.15 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.29 Pain Relevance 0.14

That the total p65 levels under these experimental conditions remained unaltered suggests that the findings shown in Fig. 6B are truly due to the modification of p65 by such experimental conditions.

Regulation (modification) of p65

4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780735 Disease Relevance 0.10 Pain Relevance 0

General Comments

This test has worked.