INT1706

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Context Info
Confidence 0.47
First Reported 1978
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 10.70
Pain Relevance 15.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
superior 3
nerve 2
PCA 2
lymph node 1
thyroid 1
PCa (Homo sapiens)
Pain Link Frequency Relevance Heat
Patient controlled alalgesia 108 100.00 Very High Very High Very High
analgesia 49 100.00 Very High Very High Very High
depression 1 100.00 Very High Very High Very High
Opioid 59 99.96 Very High Very High Very High
Morphine 32 99.96 Very High Very High Very High
palliative 4 99.84 Very High Very High Very High
Pain management 4 99.80 Very High Very High Very High
Pain 86 99.38 Very High Very High Very High
corticosteroid 6 99.28 Very High Very High Very High
dexamethasone 9 99.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Prostate Cancer 169 100.00 Very High Very High Very High
Reprotox - General 1 56 100.00 Very High Very High Very High
Depression 4 100.00 Very High Very High Very High
Pain 93 99.80 Very High Very High Very High
Death 7 99.76 Very High Very High Very High
Osteoporosis 47 99.60 Very High Very High Very High
Metastasis 46 99.36 Very High Very High Very High
Vomiting 16 99.28 Very High Very High Very High
Disease 36 99.24 Very High Very High Very High
Hyperplasia 5 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reducing the prescribed IFRT dose from 35 Gy to 20 Gy produced a greater decrease in the mean dose to the PCA and the thyroid, than the change from mantle RT to IFRT.
Negative_regulation (decrease) of PCA in thyroid
1) Confidence 0.47 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1847517 Disease Relevance 0.43 Pain Relevance 0
Electrical stimulation of the superior laryngeal nerve caused depression of AN and PCA activity, and hence does not reproduce the effects of negative pressure.
Negative_regulation (depression) of PCA in PCA associated with depression
2) Confidence 0.42 Published 1984 Journal J Appl Physiol Section Abstract Doc Link 6706780 Disease Relevance 0.10 Pain Relevance 0.24
These data clearly suggest that n-alcohols and anesthetics readily inhibit the LPS-stimulatory action on monocytic PCA.
Negative_regulation (inhibit) of PCA
3) Confidence 0.37 Published 1991 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 1685419 Disease Relevance 0.16 Pain Relevance 0.06
Importantly, the percent reduction in LPS-induced PCA was much more pronounced than that in non-challenged PCA. 5.
Negative_regulation (reduction) of PCA
4) Confidence 0.37 Published 1991 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 1685419 Disease Relevance 0.18 Pain Relevance 0.07
However, ethanol dose-dependently inhibited LPS-induced PCA in isolated human monocytes. 3.
Negative_regulation (inhibited) of PCA in monocytes
5) Confidence 0.37 Published 1991 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 1685419 Disease Relevance 0.17 Pain Relevance 0.09
The results suggest that dexamethasone 8 mg IV is the minimum effective dose for the reduction of PCA morphine-related nausea and vomiting.
Negative_regulation (reduction) of PCA associated with vomiting, patient controlled alalgesia, dexamethasone and morphine
6) Confidence 0.36 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041600 Disease Relevance 1.06 Pain Relevance 1.60
PCA is not limited to palliative treatment; it can be used in many circonstances during each evolutionary step of the cancer, temporarily or for longer periods, at the hospital and at home as well.
Neg (not) Negative_regulation (limited) of PCA associated with cancer, palliative and analgesia
7) Confidence 0.36 Published 1995 Journal Cah Anesthesiol Section Abstract Doc Link 8745652 Disease Relevance 0.50 Pain Relevance 1.06
The cost effectiveness of PCA for pain management is an unresolved question because of the variability in methods used to determine costs and expenses, the different settings and patient populations in which PCA is applied, the different means to organise its management and the fact that it is a rapidly evolving technology during an era of changing reimbursement practices.
Negative_regulation (effectiveness) of PCA associated with pain management and patient controlled alalgesia
8) Confidence 0.36 Published 1997 Journal Pharmacoeconomics Section Abstract Doc Link 10169664 Disease Relevance 0.22 Pain Relevance 1.28
RESULTS: The patients who received fentanyl demonstrated a significant decrease in their mean pain VAS, an increase in the time to first PCA bolus, and a 41% reduction in the total PCA morphine received.
Negative_regulation (reduction) of PCA
9) Confidence 0.36 Published 2006 Journal Spine Section Body Doc Link 17047539 Disease Relevance 0 Pain Relevance 0
Effectiveness of PCA was judged superior by about 68% of patients when compared with previously experienced conventional postoperative analgesia.
Negative_regulation (Effectiveness) of PCA in superior associated with analgesia
10) Confidence 0.36 Published 1985 Journal Langenbecks Arch Chir Section Abstract Doc Link 4094511 Disease Relevance 0.32 Pain Relevance 1.08
Effectiveness of PCA was judged superior by about 84% of patients when compared with previously experienced conventional postoperative analgesia.
Negative_regulation (Effectiveness) of PCA in superior associated with analgesia
11) Confidence 0.36 Published 1985 Journal Anaesthesist Section Abstract Doc Link 4073443 Disease Relevance 0.22 Pain Relevance 0.84
Effectiveness of PCA was judged superior by about 73% of patients when compared with previously experienced conventional postoperative analgesia.
Negative_regulation (Effectiveness) of PCA in superior associated with analgesia
12) Confidence 0.36 Published 1986 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 2882642 Disease Relevance 0.49 Pain Relevance 0.76
We previously determined that a single dose of metoclopramide could significantly reduce the patient-controlled analgesia (PCA) morphine requirements of women undergoing prostaglandin-induced termination of pregnancy.
Negative_regulation (reduce) of PCA associated with spontaneous abortion, patient controlled alalgesia and morphine
13) Confidence 0.36 Published 1992 Journal Anesth. Analg. Section Abstract Doc Link 1416131 Disease Relevance 0.31 Pain Relevance 0.64
This was associated with a 66% reduction in PCA morphine received by the time of fetal delivery (P < 0.05).
Negative_regulation (reduction) of PCA associated with patient controlled alalgesia and morphine
14) Confidence 0.36 Published 1992 Journal Anesth. Analg. Section Abstract Doc Link 1416131 Disease Relevance 0.45 Pain Relevance 1.13
Water on the larynx transiently abolished both PCA and diaphragm discharge; but EMG activity returned to the PCA muscles before the diaphragm.
Negative_regulation (abolished) of PCA in diaphragm
15) Confidence 0.36 Published 1978 Journal Respir Physiol Section Abstract Doc Link 741102 Disease Relevance 0 Pain Relevance 0.10
Informations of PCA (incremental dose, lock-out interval, back ground infusion, number of hours PCA not activated and total morphine consumed) and epidural infusion (concentration of mixture of local anesthetic with opioid and its volume consumed during first 24 hours) were also collected.
Negative_regulation (number) of PCA
16) Confidence 0.36 Published 2005 Journal Saudi Med J Section Body Doc Link 15770310 Disease Relevance 0.07 Pain Relevance 0
CONCLUSION: In continuous popliteal sciatic block, local anesthetic administered as an automated regular bolus in conjunction with PCA provided similar pain relief as a continuous infusion technique combined with PCA; however, the new dosing regimen reduced the need for additional PCA and the overall consumption of local anesthetic.


Negative_regulation (reduced) of PCA
17) Confidence 0.36 Published 2009 Journal Anesthesiology Section Body Doc Link 19104182 Disease Relevance 0 Pain Relevance 0
Fulfilling the exclusion criteria, seven patients had to be excluded from analysis (n = 3, on PCA for less than 7 days; n = 4, PCA was finished before death).
Negative_regulation (finished) of PCA
18) Confidence 0.36 Published 2008 Journal Support Care Cancer Section Body Doc Link 17960428 Disease Relevance 0 Pain Relevance 0
Both expiratory and inspiratory PCA activity declined during sleep--the former more so than the latter.
Negative_regulation (declined) of PCA in PCA
19) Confidence 0.35 Published 1978 Journal Sleep Section Abstract Doc Link 227023 Disease Relevance 0 Pain Relevance 0.21
We conclude that high-TAES produced a significant decrease in the PCA opioid requirement and opioid-related side effects after low intraabdominal surgery.
Negative_regulation (decrease) of PCA associated with patient controlled alalgesia and opioid
20) Confidence 0.35 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9249122 Disease Relevance 0.53 Pain Relevance 1.14

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