INT170603

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Context Info
Confidence 0.32
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.18
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
CD86 2
T cells 2
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 14 100.00 Very High Very High Very High
chemokine 20 95.04 Very High Very High Very High
Inflammation 60 91.92 High High
rheumatoid arthritis 52 91.40 High High
Inflammatory mediators 6 90.96 High High
cytokine 35 73.48 Quite High
pruritus 1 59.56 Quite High
dexamethasone 1 23.12 Low Low
aspirin 3 21.76 Low Low
methotrexate 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 13 100.00 Very High Very High Very High
Cancer 137 96.56 Very High Very High Very High
INFLAMMATION 72 91.92 High High
Rheumatoid Arthritis 52 91.40 High High
Solid Tumor 3 82.64 Quite High
Breast Cancer 8 80.64 Quite High
Immunization 4 75.96 Quite High
Infection 35 75.32 Quite High
Lymphopenia 2 70.92 Quite High
Disease 22 69.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dysfunctional T cells appear to be provoked, at least in part, through inadequate stimulation by immature DC [99], lacking costimulatory molecule and CD40 ligand expression.
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of CD40 in T cells
1) Confidence 0.32 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.64 Pain Relevance 0.11
During these processes DCs undergo diverse phenotypical and functional changes such as reduced phagocytic ability, upregulated cell surface expression of co-stimulatory molecules and adhesion proteins, such as CD86, CD83, CD54, CD40, and MHC II antigens.
Negative_regulation (reduced) of Gene_expression (expression) of CD40 in CD86 associated with adhesions
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.34 Pain Relevance 0.08
The loss of tolerance model due to CD40–CD40L activation signals
Negative_regulation (loss) of Gene_expression (signals) of CD40 associated with tolerance
3) Confidence 0.21 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.85 Pain Relevance 0.45
Despite uniform expression of CD40 on ??
Negative_regulation (Despite) of Gene_expression (expression) of CD40
4) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.23 Pain Relevance 0.14
B1 p50 is necessary if a sufficient inhibition of NF-?
Negative_regulation (inhibition) of Gene_expression (necessary) of p50
5) Confidence 0.12 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.12 Pain Relevance 0

General Comments

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