INT170691

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Context Info
Confidence 0.88
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Siah1a) cytosol (Siah1a) nucleus (Siah1a)
cell cycle (Siah1a) ligase activity (Siah1a) cytoplasm (Siah1a)
Anatomy Link Frequency
finger 1
Siah1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 12 50.00 Quite Low
Glutamate 36 43.60 Quite Low
Neuronal excitability 3 22.64 Low Low
imagery 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 18 93.44 High High
Cancer 3 86.40 High High
Apoptosis 3 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although an obvious decrease in receptor levels in the presence of Siah1a was not detected (figure 3), it is possible that introduction of high levels of Siah1a changed the rate of mGluR degradation such that a new equilibrium was reached with lower levels of active receptor than in the absence of Siah1a.
Protein_catabolism (degradation) of Siah1a
1) Confidence 0.88 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.09 Pain Relevance 0
Does Siah1a target group I mGluRs for proteolysis?
Protein_catabolism (proteolysis) of Siah1a
2) Confidence 0.57 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.08 Pain Relevance 0
The presence of a RING finger domain in the N-terminus of the mammalian homologue of SinA, "Siah", suggests it may be involved in targeting specific proteins for degradation in the proteasome as a ubiquitin ligase [32].
Protein_catabolism (degradation) of Siah in finger
3) Confidence 0.57 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.17 Pain Relevance 0

General Comments

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