INT170695

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2001
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 1.19
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Siah1a) cytosol (Siah1a) nucleus (Siah1a)
cell cycle (Siah1a) ligase activity (Siah1a) cytoplasm (Siah1a)
Anatomy Link Frequency
neurons 1
tail 1
SCG 1
Siah1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 68 99.12 Very High Very High Very High
Glutamate 204 90.48 High High
imagery 34 79.32 Quite High
addiction 17 19.60 Low Low
Neuronal excitability 17 9.48 Low Low
tetrodotoxin 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 17 97.76 Very High Very High Very High
Cancer 17 97.12 Very High Very High Very High
Ganglion Cysts 102 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, binding of Siah1a to the C-terminus of group I mGluRs may occlude the region or regions responsible for G protein activation.
Siah1a Binding (binding) of
1) Confidence 0.48 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.04
To assess the role of Siah1a binding, specific group I mGluRs were heterologously expressed in sympathetic neurons from the rat superior cervical ganglion (SCG), which do not natively express mGluRs [37,38].
Siah1a Binding (binding) of in SCG associated with ganglion cysts
2) Confidence 0.48 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.34 Pain Relevance 0
The site of Siah1a interaction is ~50 residues distal to that site [36].
Siah1a Binding (interaction) of
3) Confidence 0.48 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
This deletion construct was as effective in attenuating group I mGluR function as the wild type Siah1a, providing supporting evidence that the effect of Siah1a resulted from its physical association with the receptors, rather than through a resulting reduction in receptor expression levels.
Siah1a Binding (association) of
4) Confidence 0.48 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.08 Pain Relevance 0.04
This model predicts that Siah1a association produces its effect by disrupting the interaction of CaM with the group I mGluRs.
Siah1a Binding (association) of
5) Confidence 0.48 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
However, Siah1a had no detectable effect on mGluR2-mediated calcium current inhibition, consistent with reports demonstrating that Siah1a does not bind to group II mGluRs [36].
Siah1a Neg (not) Binding (bind) of
6) Confidence 0.48 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.15
Alternatively, Siah1a binding may alter the 'normal' interactions of the receptors with scaffolding proteins or may cause the receptors to be targeted for degradation in the proteasome, effectively reducing the number of receptors that are 'correctly' assembled, or the number of functional receptors at the membrane.
Siah1a Binding (binding) of
7) Confidence 0.48 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.03
Further studies will be needed to determine if group I mGluRs and Siah1a interact physiologically, and whether this interaction has functional consequences.
Siah1a Binding (interact) of
8) Confidence 0.48 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
All neurons except those injected with the mGluR1a-GFP or GFP-Siah1a-CT constructs, were co-injected with "enhanced" green fluorescent protein cDNA (0.005 ?
Siah1a Neg (except) Binding (injected) of in neurons
9) Confidence 0.37 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
To date the functional consequences of Siah1a association with group I mGluRs are unknown.
Siah1a Binding (association) of
10) Confidence 0.37 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.33 Pain Relevance 0
Finally, coexpression of CaM reversed the effect of Siah1a on mGluR5b, indicating that the interaction of CaM and Siah1a in binding to group I mGluRs plays a novel and important role in mGluR function.


Siah1a Binding (interaction) of
11) Confidence 0.37 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.07 Pain Relevance 0.03
By analogy to group III mGluRs, the ability of Siah1a to compete with CaM for binding to group I mGluRs was considered a potential mechanism for the actions of Siah1a on group I mGluR-mediated calcium current inhibition.
Siah1a Binding (binding) of
12) Confidence 0.37 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
More recently, an interaction between Siah1a and the C-terminal tail of group I mGluRs was demonstrated [36].
Siah1a Binding (interaction) of in tail
13) Confidence 0.37 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.19 Pain Relevance 0
Association of Siah1a with group I mGluRs can also prevent the interaction of CaM and the receptor [36].
Siah1a Binding (Association) of
14) Confidence 0.37 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.06
Recent work has shown that Siah can bind group I metabotropic glutamate receptors (mGluRs), but the functional consequences of this interaction are unknown.


Siah Binding (bind) of associated with glutamate receptor
15) Confidence 0.35 Published 2001 Journal BMC Neurosci Section Abstract Doc Link PMC58838 Disease Relevance 0.08 Pain Relevance 0.09
These data supported the conclusion that the attenuation of mGluR signaling induced by Siah1a expression was likely a direct consequence of Siah/mGluR association rather than a result of targeting of the receptors to the proteosome.
Siah Binding (association) of
16) Confidence 0.35 Published 2001 Journal BMC Neurosci Section Abstract Doc Link PMC58838 Disease Relevance 0.06 Pain Relevance 0.08
In addition, the data suggest that the binding of CaM and Siah may play an important role in the regulation of group I mGluR function.



Siah Binding (binding) of
17) Confidence 0.31 Published 2001 Journal BMC Neurosci Section Abstract Doc Link PMC58838 Disease Relevance 0.05 Pain Relevance 0.07

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