INT170700

Context Info Confidence 0.50 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.36 Pain Relevance 0.13

cell differentiation (Siah1a) cytosol (Siah1a) nucleus (Siah1a) cell cycle (Siah1a) ligase activity (Siah1a) cytoplasm (Siah1a)

Siah1a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate 36 77.52 addiction 3 59.04 Glutamate receptor 12 50.00 imagery 6 5.00 tetrodotoxin 3 5.00 Neuronal excitability 3 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 18 87.92 Apoptosis 3 53.80 Cancer 3 53.16

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Next, when CaM was coexpressed with mGluR5b and Siah1a, calcium current modulation was significantly increased (over that in cells expressing mGluR5b and Siah1a) to 25 ± 5% (n = 12; figure 6).

Positive_regulation (increased) of Gene_expression (coexpressed) of Siah1a

1) Confidence 0.50 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

Finally, the effect of CaM overexpression on Siah1a function was assessed.

Positive_regulation (overexpression) of Gene_expression (overexpression) of Siah1a

2) Confidence 0.50 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.36 Pain Relevance 0.06

The reduction in group I mGluR signaling induced by Siah1a expression may be attributed to several possible mechanisms.

Positive_regulation (induced) of Gene_expression (expression) of Siah1a

3) Confidence 0.50 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.06

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