INT170710

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.10
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Siah1a) cytosol (Siah1a) nucleus (Siah1a)
cell cycle (Siah1a) ligase activity (Siah1a) cytoplasm (Siah1a)
Siah1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 48 99.30 Very High Very High Very High
Glutamate receptor 16 50.00 Quite Low
addiction 4 12.28 Low Low
imagery 8 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Neuronal excitability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 24 98.80 Very High Very High Very High
Cancer 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells expressing mGluR2 alone exhibited 57 ± 5% inhibition of calcium current in response to glutamate (n = 6), while those coexpressing Siah1a were inhibited 61 ± 2% (n = 6; figure 2).
Negative_regulation (inhibited) of Siah1a associated with glutamate
1) Confidence 0.43 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.12
With Siah1a and Siah1a + CaM inhibition was 7 ± 6% (n = 3) and 30 ± 18% (n = 3), respectively.
Negative_regulation (inhibition) of Siah1a
2) Confidence 0.43 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
Although an obvious decrease in receptor levels in the presence of Siah1a was not detected (figure 3), it is possible that introduction of high levels of Siah1a changed the rate of mGluR degradation such that a new equilibrium was reached with lower levels of active receptor than in the absence of Siah1a.
Negative_regulation (decrease) of Siah1a
3) Confidence 0.43 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.10 Pain Relevance 0
With Siah1a and Siah1a + CaM inhibition was 7 ± 6% (n = 3) and 30 ± 18% (n = 3), respectively.
Negative_regulation (inhibition) of Siah1a
4) Confidence 0.19 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

General Comments

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