INT170713

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.36
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calm2) nucleoplasm (Calm2) cytoskeleton (Calm2)
cell cycle (Calm2) cellular_component (Calm2) biological_process (Calm2)
Calm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 36 68.96 Quite High
addiction 20 58.24 Quite High
Glutamate receptor 12 50.00 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
tetrodotoxin 8 5.00 Very Low Very Low Very Low
Neuronal excitability 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 32 87.12 High High
Apoptosis 3 53.96 Quite High
Cancer 3 53.32 Quite High
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, overexpression of CaM was tested for its ability to reverse the effect of Siah1a.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CaM
1) Confidence 0.39 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
Finally, the effect of CaM overexpression on Siah1a function was assessed.


Positive_regulation (overexpression) of Gene_expression (overexpression) of CaM
2) Confidence 0.39 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.36 Pain Relevance 0.06
Next, when CaM was coexpressed with mGluR5b and Siah1a, calcium current modulation was significantly increased (over that in cells expressing mGluR5b and Siah1a) to 25 ± 5% (n = 12; figure 6).
Positive_regulation (increased) of Gene_expression (coexpressed) of CaM
3) Confidence 0.28 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
Second, a single tethered CaM would be insufficient to trigger persistent activation of CaMKII, which has ?
Positive_regulation (tethered) of Gene_expression (tethered) of CaM
4) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0

General Comments

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