INT170714

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2001
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.71
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Siah1a) cytosol (Siah1a) nucleus (Siah1a)
cell cycle (Siah1a) ligase activity (Siah1a) cytoplasm (Siah1a)
Anatomy Link Frequency
neurons 4
Siah1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 16 96.44 Very High Very High Very High
Glutamate 48 80.24 Quite High
addiction 4 69.52 Quite High
imagery 8 47.28 Quite Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Neuronal excitability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 24 99.20 Very High Very High Very High
Apoptosis 4 54.36 Quite High
Cancer 4 53.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the role of Siah1a expression on mGluR function, SCG neurons were injected with cDNA encoding several group I mGluRs (mGluR1, 5 and their splice variants) with or without Siah1a expression.
Spec (examine) Regulation (role) of Spec (examine) Gene_expression (expression) of Siah1a in neurons associated with ganglion cysts
1) Confidence 0.61 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.26 Pain Relevance 0.10
Finally, the effect of CaM overexpression on Siah1a function was assessed.


Regulation (effect) of Gene_expression (overexpression) of Siah1a
2) Confidence 0.45 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.36 Pain Relevance 0.06
To test whether Siah1a expression altered the surface expression of group I mGluRs, the surface distribution of mGluR5a-myc was examined in the absence and presence of Siah1a.
Spec (whether) Regulation (altered) of Spec (whether) Gene_expression (expression) of Siah1a
3) Confidence 0.45 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
The effects of coexpression of Siah on group I mGluR signaling were examined using heterologous expression in rat sympathetic, superior cervical ganglion neurons.
Spec (examined) Regulation (effects) of Gene_expression (coexpression) of Siah in neurons associated with ganglion cysts
4) Confidence 0.27 Published 2001 Journal BMC Neurosci Section Abstract Doc Link PMC58838 Disease Relevance 0.10 Pain Relevance 0.09

General Comments

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