INT170714

Context Info Confidence 0.61 First Reported 2001 Last Reported 2001 Negated 0 Speculated 3 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.71 Pain Relevance 0.25

cell differentiation (Siah1a) cytosol (Siah1a) nucleus (Siah1a) cell cycle (Siah1a) ligase activity (Siah1a) cytoplasm (Siah1a)

Anatomy Link Frequency neurons 4 Siah1a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate receptor 16 96.44 Glutamate 48 80.24 addiction 4 69.52 imagery 8 47.28 tetrodotoxin 4 5.00 Neuronal excitability 4 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 24 99.20 Apoptosis 4 54.36 Cancer 4 53.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To examine the role of Siah1a expression on mGluR function, SCG neurons were injected with cDNA encoding several group I mGluRs (mGluR1, 5 and their splice variants) with or without Siah1a expression.

Spec (examine) Regulation (role) of Spec (examine) Gene_expression (expression) of Siah1a in neurons associated with ganglion cysts

1) Confidence 0.61 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.26 Pain Relevance 0.10

Finally, the effect of CaM overexpression on Siah1a function was assessed.

Regulation (effect) of Gene_expression (overexpression) of Siah1a

2) Confidence 0.45 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.36 Pain Relevance 0.06

To test whether Siah1a expression altered the surface expression of group I mGluRs, the surface distribution of mGluR5a-myc was examined in the absence and presence of Siah1a.

Spec (whether) Regulation (altered) of Spec (whether) Gene_expression (expression) of Siah1a

3) Confidence 0.45 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

The effects of coexpression of Siah on group I mGluR signaling were examined using heterologous expression in rat sympathetic, superior cervical ganglion neurons.

Spec (examined) Regulation (effects) of Gene_expression (coexpression) of Siah in neurons associated with ganglion cysts

4) Confidence 0.27 Published 2001 Journal BMC Neurosci Section Abstract Doc Link PMC58838 Disease Relevance 0.10 Pain Relevance 0.09

General Comments

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