INT170734

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.87
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Scd1) endoplasmic reticulum (Scd1) lipid metabolic process (Scd1)
Anatomy Link Frequency
hepatocytes 4
liver 2
Scd1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 33 93.48 High High
Bioavailability 3 42.32 Quite Low
Inflammation 48 5.00 Very Low Very Low Very Low
agonist 33 5.00 Very Low Very Low Very Low
alcohol 15 5.00 Very Low Very Low Very Low
Bile 15 5.00 Very Low Very Low Very Low
chemokine 13 5.00 Very Low Very Low Very Low
Kinase C 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 73 100.00 Very High Very High Very High
Hypertension 71 99.96 Very High Very High Very High
Injury 26 99.86 Very High Very High Very High
Fatty Liver 189 99.68 Very High Very High Very High
Apoptosis 21 99.14 Very High Very High Very High
Adhesions 14 94.84 High High
Cirrhosis 24 93.48 High High
Increased Venous Pressure Under Development 7 91.00 High High
Vasculitis 1 87.40 High High
Fibrosis 24 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, although Scd1-null mice are resistant to hepatic steatosis, they are more susceptible to liver injury while increased SCD-1 expression during NAFLD reflects a compensatory beneficial effect on increasing MUFA synthesis and storage of excessive FFAs as triglycerides.
Positive_regulation (increased) of Gene_expression (expression) of SCD-1 in liver associated with fatty liver and injury
1) Confidence 0.48 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.01 Pain Relevance 0.05
Furthermore, inhibition of SCD-1 sensitized hepatocytes to SFA-induced apoptosis, and mice fed with a high-fat diet showed increased SCD-1 expression and hepatic accumulation of MUFA.
Positive_regulation (accumulation) of Gene_expression (expression) of SCD-1 in hepatocytes associated with apoptosis
2) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.06 Pain Relevance 0.04
Furthermore, inhibition of SCD-1 sensitized hepatocytes to SFA-induced apoptosis, and mice fed with a high-fat diet showed increased SCD-1 expression and hepatic accumulation of MUFA.
Positive_regulation (increased) of Gene_expression (expression) of SCD-1 in hepatocytes associated with apoptosis
3) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.06 Pain Relevance 0.04
Multiple prospective screening studies have found roughly a third of adult patients with SCD have PH as defined by a TRV of ?
Positive_regulation (with) of Gene_expression (have) of SCD associated with sickle cell anemia and hypertension
4) Confidence 0.13 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.12 Pain Relevance 0
In this way, free radical generation in SCD may contribute to the propagation of vaso-occlusion.


Positive_regulation (generation) of Gene_expression (generation) of SCD associated with sickle cell anemia
5) Confidence 0.11 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.63 Pain Relevance 0

General Comments

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