INT170738

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 28
Disease Relevance 25.49
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
endothelial cells 2
endothelium 2
heart 2
Neutrophils 2
T-cells 2
Icam1 (Mus musculus)
Icam1 - K469E (2)
Pain Link Frequency Relevance Heat
metalloproteinase 79 100.00 Very High Very High Very High
Inflammatory mediators 4 99.14 Very High Very High Very High
chemokine 101 99.10 Very High Very High Very High
cytokine 120 98.78 Very High Very High Very High
Inflammation 287 98.48 Very High Very High Very High
Multiple sclerosis 1 96.32 Very High Very High Very High
pruritus 59 95.60 Very High Very High Very High
psoriasis 39 90.76 High High
Angina 80 90.04 High High
ischemia 23 86.76 High High
Disease Link Frequency Relevance Heat
Adhesions 324 100.00 Very High Very High Very High
Myocardial Infarction 152 99.76 Very High Very High Very High
Cardiovascular Disease 81 99.76 Very High Very High Very High
Coronary Heart Disease 214 99.24 Very High Very High Very High
Diabetes Mellitus 71 98.96 Very High Very High Very High
INFLAMMATION 317 98.94 Very High Very High Very High
Stroke 66 98.92 Very High Very High Very High
Disease 186 98.88 Very High Very High Very High
Atherosclerosis 95 98.04 Very High Very High Very High
Metastasis 5 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, a Slovenian study reported that the K469E polymorphism of the ICAM-1 gene was not associated with MI in subjects with type 2 diabetes.15 The discrepancy among the studies could be due to selection of patient groups from different ethnic populations, variable sample sizes or different interactions of the genetic background with environmental factors.
ICAM-1 gene Binding (associated) of associated with diabetes mellitus and myocardial infarction
1) Confidence 0.37 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.33 Pain Relevance 0.10
On the other hand, McGlinchey et al13 found no association between the ICAM-1 K469E polymorphism and CHD in a well-defined Irish population.
ICAM-1 (K469E) Neg (no) Binding (association) of associated with coronary heart disease
2) Confidence 0.37 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.35 Pain Relevance 0.04
In conclusion, our results suggest that the KK and EK genotypes of the ICAM-1 gene polymorphism in codon 469 are associated with the risk for CHD development in Egyptians.
ICAM-1 gene Binding (associated) of associated with coronary heart disease
3) Confidence 0.37 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.20 Pain Relevance 0.19
High values for MMP-9 and low values for ICAM-1 were associated with high levels of free radicals.
ICAM-1 Binding (associated) of associated with metalloproteinase
4) Confidence 0.35 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.67 Pain Relevance 0.26
Elevated concentrations of ICAM-1 were reported to be associated with an increased risk of stroke 6 whereas no correlation was found between the expression of ICAM-1 and the severity of symptomatic carotid disease 26.
ICAM-1 Binding (associated) of associated with stroke and disease
5) Confidence 0.35 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.67 Pain Relevance 0.03
ICAM-1 is one of the major ligands that binds to ?
ICAM Binding (binds) of
6) Confidence 0.33 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.16 Pain Relevance 0.18
Interaction of ICAM-1 expressed on the surface of vascular endothelial cells with the ?
ICAM Binding (Interaction) of in endothelial cells
7) Confidence 0.33 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.33 Pain Relevance 0.08
This study aimed to investigate the association of K469E polymorphism of the ICAM-1 gene and soluble ICAM-1 (sICAM-1) serum level with coronary heart disease (CHD) in Egyptian subjects.


soluble ICAM-1 (K469E) Binding (association) of in heart associated with coronary heart disease
8) Confidence 0.31 Published 2010 Journal Annals of Saudi Medicine Section Abstract Doc Link PMC2994157 Disease Relevance 1.12 Pain Relevance 0.16
This study aimed to investigate the association of K469E polymorphism of the ICAM-1 gene and soluble ICAM-1 (sICAM-1) serum level with coronary heart disease (CHD) in Egyptian subjects.


sICAM-1 Binding (association) of in heart associated with coronary heart disease
9) Confidence 0.31 Published 2010 Journal Annals of Saudi Medicine Section Abstract Doc Link PMC2994157 Disease Relevance 1.12 Pain Relevance 0.16
However, Zakai et al19 studied the relation between inflammation and cardiovascular disease risk (CVD) in older adults, and they found that sICAM-1 was associated with CVD in women only.
sICAM-1 Binding (associated) of associated with inflammation and cardiovascular disease
10) Confidence 0.31 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.38 Pain Relevance 0.22
For example, ICAM-2, a ligand for ?
ICAM Binding (ligand) of
11) Confidence 0.28 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.07 Pain Relevance 0.07
For example, ICAM-2, a ligand for ?
ICAM Binding (example) of
12) Confidence 0.28 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.07 Pain Relevance 0.07
Lung sections were also stained with antibodies to the cell-adhesion molecule ICAM-1, the goblet cell marker Muc-5A, and the Th2 marker T1/ST2 (Santa Cruz BioTech, Santa Cruz, CA).


ICAM-1 Binding (stained) of in Lung associated with adhesions
13) Confidence 0.22 Published 2006 Journal Virol J Section Body Doc Link PMC1488829 Disease Relevance 0.35 Pain Relevance 0.12
Neutrophils also recognize the adhesion molecule intercellular adhesion molecule-1 (ICAM-1).
intercellular adhesion molecule-1 Binding (recognize) of in Neutrophils associated with adhesions
14) Confidence 0.21 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.29 Pain Relevance 0.17
Neutrophils also recognize the adhesion molecule intercellular adhesion molecule-1 (ICAM-1).
ICAM-1 Binding (recognize) of in Neutrophils associated with adhesions
15) Confidence 0.21 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.29 Pain Relevance 0.17
LFA-1/ICAM-1 interaction played a critical role in the pMV-absorption.
ICAM-1 Binding (interaction) of
16) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0
B on downstream inflammatory mediators, we studied the abundance of the mRNA for intercellular adhesion molecule 1 (ICAM-1), which contains a consensus sequence for binding of NF-?
intercellular adhesion molecule 1 Binding (contains) of associated with inflammatory mediators and adhesions
17) Confidence 0.18 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.25 Pain Relevance 0.15
B on downstream inflammatory mediators, we studied the abundance of the mRNA for intercellular adhesion molecule 1 (ICAM-1), which contains a consensus sequence for binding of NF-?
ICAM-1 Binding (contains) of associated with inflammatory mediators and adhesions
18) Confidence 0.18 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.25 Pain Relevance 0.15
More recently, cytokines (e.g., interleukin-6) and soluble adhesion molecules (e.g., intercellular adhesion molecule-1, vascular cell adhesion molecule-1) have been associated with both risk factors and disease [3].
intercellular adhesion molecule-1 Binding (associated) of associated with disease, adhesions and cytokine
19) Confidence 0.16 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 1.46 Pain Relevance 0.13
vessels immunoreactive for intercellular cell adhesion molecule (ICAM)-1,
intercellular cell adhesion molecule Binding (immunoreactive) of in vessels associated with adhesions
20) Confidence 0.11 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2221678 Disease Relevance 1.95 Pain Relevance 0.51

General Comments

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