INT170739

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.02
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acsl1) endoplasmic reticulum (Acsl1) plasma membrane (Acsl1)
peroxisome (Acsl1) ligase activity (Acsl1) lipid metabolic process (Acsl1)
Anatomy Link Frequency
CPA 1
endothelium 1
T cells 1
vascular endothelium 1
Acsl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 8 99.48 Very High Very High Very High
Pain 2 99.20 Very High Very High Very High
Angina 11 95.04 Very High Very High Very High
rheumatoid arthritis 45 90.24 High High
Inflammation 26 86.72 High High
tolerance 12 71.44 Quite High
metalloproteinase 11 50.00 Quite Low
Arthritis 3 50.00 Quite Low
Pain score 3 38.96 Quite Low
Inflammatory response 2 30.00 Quite Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 133 100.00 Very High Very High Very High
Acute Chest Syndrome 105 100.00 Very High Very High Very High
Colorectal Cancer 32 100.00 Very High Very High Very High
Cv General 3 Under Development 9 99.48 Very High Very High Very High
Pain 5 99.20 Very High Very High Very High
Residual Neoplasm 10 99.00 Very High Very High Very High
Disease 47 97.68 Very High Very High Very High
Arrhythmias 2 Under Development 4 96.52 Very High Very High Very High
Cancer 338 95.72 Very High Very High Very High
Stable Angina Pectoris 10 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations are supported by qRT-PCR using TG or NTG cells isolated by FACS, which show that ALDH1A1 is the predominant cytoplasmic ALDH enzyme in colorectal tumors and its expression is further increased in residual tumor cells following therapy with CPA; consistent with the phenotypic increase in ALDH+ cells among the CoCSC phenotype.
Gene_expression (expression) of FACS in CPA associated with colorectal cancer and residual neoplasm
1) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.83 Pain Relevance 0
After 3 days in culture, the DiI-positive cells (Figure 11A and B, left) were analyzed by FACS for expression of CD24a and CD49f (Figure 11A and B, right).
Spec (analyzed) Gene_expression (analyzed) of FACS
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
and MMP-9 were significantly increased in ACS group (P < 0.05) (Table 2).
Gene_expression (group) of ACS associated with acute coronary syndrome
3) Confidence 0.16 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 1.12 Pain Relevance 0.17
A close-up view of a selection of differentially regulated proteins, together with their expression levels in controls and NSTE-ACS patients at different time points, is shown in Figure 2.
Gene_expression (expression) of NSTE-ACS associated with acute coronary syndrome
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.40 Pain Relevance 0
The activities of these antioxidant enzyme systems have never been directly studied during ACS, however.
Gene_expression (studied) of ACS associated with acute chest syndrome
5) Confidence 0.07 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.36 Pain Relevance 0
The vascular endothelium appears uniquely sensitive to damage from oxidizing molecules produced during VOC and ACS.
Gene_expression (produced) of ACS in vascular endothelium associated with acute chest syndrome
6) Confidence 0.07 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 1.24 Pain Relevance 0
Although endothelial production of oxidants is difficult to measure directly in human disease, these in vitro and in vivo data suggest that the endothelium of the pulmonary arteries may be involved in oxidant production during ACS.


Gene_expression (production) of ACS in endothelium associated with acute chest syndrome and disease
7) Confidence 0.07 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 1.04 Pain Relevance 0
Eighteen patients admitted into a tertiary hospital from the northwest of Spain presenting with NSTE-ACS, defined as angina pain of at least 10 min duration with troponin elevation and/or ST-T changes in the electrocardiogram, entered the study.
Gene_expression (presenting) of NSTE-ACS associated with pain, acute coronary syndrome, arrhythmias 2 under development and cva
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 1.27 Pain Relevance 0.22
Most interestingly, T cells in patients with ACS can also express the adaptor molecule, DAP12.
Gene_expression (express) of ACS in T cells associated with acute coronary syndrome
9) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.74 Pain Relevance 0.11

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