INT170742

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 6.98
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acsl1) endoplasmic reticulum (Acsl1) plasma membrane (Acsl1)
peroxisome (Acsl1) ligase activity (Acsl1) lipid metabolic process (Acsl1)
Anatomy Link Frequency
platelets 3
plasma 1
coronary artery 1
motor nerve 1
Acsl1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 20 100.00 Very High Very High Very High
nMDA receptor 8 99.84 Very High Very High Very High
Pain 39 97.12 Very High Very High Very High
Inflammation 22 80.92 Quite High
Anterior cingulate cortex 21 69.60 Quite High
allodynia 28 69.52 Quite High
cytokine 1 64.88 Quite High
Angina 4 33.52 Quite Low
chemokine 1 30.00 Quite Low
Spinal cord 12 20.08 Low Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 292 100.00 Very High Very High Very High
Acute Chest Syndrome 35 100.00 Very High Very High Very High
Depression 20 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 14 99.66 Very High Very High Very High
Hemorrhage 146 99.08 Very High Very High Very High
Necrosis 13 98.60 Very High Very High Very High
Disease 20 98.56 Very High Very High Very High
Myalgia 29 97.12 Very High Very High Very High
Coronary Artery Disease 62 95.24 Very High Very High Very High
Targeted Disruption 56 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(Ppara), acyl-CoA synthetase long-chain family 1 (Acsl1) and 3-hydroxybutyrate dehydrogenase (Bdh1), showed attenuated induction by motor nerve stimulation in p38?
Positive_regulation (induction) of Acsl1 in motor nerve
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.28 Pain Relevance 0.03
Ca2+/calmodulin-stimulated ACs are activated by NMDA receptor-mediated calcium entry and the reduction in the late phase of the formalin lick test may be due to the loss of NMDA receptor-dependent synaptic potentiation that normally lasts for several hours [16].
Positive_regulation (activated) of ACs associated with nmda receptor
2) Confidence 0.18 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.99 Pain Relevance 0.74
Interestingly, the levels of platelet-secreted glycoprotein SPARC were decreased in platelets from NSTE-ACS patients as compared to stable controls, which is consistent with a platelet secretion associated to platelet activation in NSTE-ACS.
Positive_regulation (activation) of NSTE-ACS in platelet associated with acute coronary syndrome
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.66 Pain Relevance 0
We performed the first high-resolution two-dimensional gel electrophoresis-based proteome analysis of circulating platelets from patients with non-ST segment elevation ACS (NSTE-ACS).
Positive_regulation (elevation) of ACS in platelets associated with acute coronary syndrome
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954807 Disease Relevance 0.61 Pain Relevance 0
We performed the first high-resolution two-dimensional gel electrophoresis-based proteome analysis of circulating platelets from patients with non-ST segment elevation ACS (NSTE-ACS).
Positive_regulation (elevation) of NSTE-ACS in platelets associated with acute coronary syndrome
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954807 Disease Relevance 0.61 Pain Relevance 0
Peripheral WBC counts are elevated in VOC and ACS, and WBC counts greater than 15,000 are associated with increased mortality [26,27].
Positive_regulation (elevated) of ACS associated with acute chest syndrome
6) Confidence 0.05 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.61 Pain Relevance 0
In this context, preliminary studies on platelet-poor plasma (PPP) from NSTE-ACS patients, compared to matched chronic controls, suggest that circulating SPARC levels are increased in NSTE-ACS patients (not shown).


Positive_regulation (increased) of NSTE-ACS in plasma associated with acute coronary syndrome
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.63 Pain Relevance 0
Eligibility required a clinical history of ACS accompanied by at least one of the following: electrocardiographic changes consistent with ACS, serial increases in biochemical markers of cardiac necrosis (troponin, creatinine kinase MB, creatinine phosphokinase), and documented coronary artery disease.
Positive_regulation (increases) of ACS in coronary artery associated with necrosis, acute coronary syndrome, coronary artery disease and arrhythmias 2 under development
8) Confidence 0.01 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2838680 Disease Relevance 1.21 Pain Relevance 0
We have demonstrated previously that the risk profile of the GRACE ACS population has not declined over time (it remained unchanged for ST-elevation ACS and increased for ST-depression ACS),4 and the changes in bleeding in this report take account of the risk score over time.
Positive_regulation (increased) of ACS associated with acute coronary syndrome, depression and hemorrhage
9) Confidence 0.01 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2838680 Disease Relevance 1.38 Pain Relevance 0.09

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