INT170743

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Scd1) endoplasmic reticulum (Scd1) lipid metabolic process (Scd1)
Anatomy Link Frequency
liver 2
Scd1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 3 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Pain score 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
qutenza 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 46 100.00 Very High Very High Very High
Acute Chest Syndrome 35 98.60 Very High Very High Very High
Fatty Liver 1 98.00 Very High Very High Very High
Targeted Disruption 5 96.04 Very High Very High Very High
Disease 4 91.28 High High
Obesity 7 89.40 High High
Adhesions 12 79.84 Quite High
Hemoglobinopathy 1 74.56 Quite High
Hyperhomocysteinemia 2 36.92 Quite Low
Increased Venous Pressure Under Development 1 28.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a more mechanistic fashion, recent studies have also suggested EGCG may alter food digestibility [15,36] and downregulate stearoyl-CoA desaturase (SCD1) gene expression [15], which may reduce adiposity, decrease lipid synthesis and increase liver fatty acid oxidation, as was found in SCD1 knockout mice [15,37].
Negative_regulation (reduce) of Gene_expression (expression) of SCD1 in liver associated with targeted disruption and fatty liver
1) Confidence 0.38 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2276475 Disease Relevance 0.35 Pain Relevance 0
Further work is necessary to define more clearly the oxidant/antioxidant profile of SCD patients at baseline and during VOCs, including ACS, and to examine the clinical effect of pharmacologic intervention to reduce oxidant production in SCD.
Negative_regulation (reduce) of Gene_expression (production) of SCD associated with sickle cell anemia and acute chest syndrome
2) Confidence 0.10 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 1.22 Pain Relevance 0

General Comments

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