INT170746

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Context Info
Confidence 0.20
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.30
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (REM1) GTPase activity (REM1)
Anatomy Link Frequency
eye 2
REM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 25 98.26 Very High Very High Very High
agonist 16 88.44 High High
depression 92 86.28 High High
primary somatosensory cortex 50 70.00 Quite High
fluoxetine 1 52.08 Quite High
antidepressant 68 15.28 Low Low
sNRI 8 10.96 Low Low
Hippocampus 63 5.00 Very Low Very Low Very Low
withdrawal 16 5.00 Very Low Very Low Very Low
Neurotransmitter 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 1 94.12 High High
Myalgia 1 93.76 High High
Eosinophilia 1 93.44 High High
Depression 108 86.28 High High
Apnoea 54 83.72 Quite High
Affective Disorder 10 55.44 Quite High
Sleep Disorders 21 46.88 Quite Low
Aids-related Complex 35 5.00 Very Low Very Low Very Low
Recurrence 16 5.00 Very Low Very Low Very Low
Depressive Disorder 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast agomelatine did not change rapid eye movement (REM) latency, amount of REM, or REM density.49
Neg (not) Regulation (change) of REM in eye
1) Confidence 0.20 Published 2010 Journal Core evidence Section Body Doc Link PMC2899775 Disease Relevance 0.35 Pain Relevance 0.15
In contrast agomelatine did not change rapid eye movement (REM) latency, amount of REM, or REM density.49
Neg (not) Regulation (change) of REM in eye
2) Confidence 0.20 Published 2010 Journal Core evidence Section Body Doc Link PMC2899775 Disease Relevance 0.35 Pain Relevance 0.15
Data also suggest that the beneficial effects of SSRIs on sleep-disordered breathing are most pronounced in non-REM sleep, with little or no change in REM events [27,28].
Neg (little) Regulation (change) of REM associated with ssri
3) Confidence 0.10 Published 2001 Journal Respir Res Section Body Doc Link PMC59518 Disease Relevance 0.60 Pain Relevance 0.23
The discrepancy is partially explained by the fact that these studies did not attempt to sort the separate contributions of SWS and REM sleep to IEG expression.
Regulation (contributions) of REM
4) Confidence 0.03 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.04

General Comments

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