INT170754

Context Info Confidence 0.78 First Reported 2000 Last Reported 2011 Negated 2 Speculated 1 Reported most in Body Documents 121 Total Number 129 Disease Relevance 66.78 Pain Relevance 15.60

Anatomy Link Frequency T cells 13 NK cells 11 monocytes 3 microglial cells 3 stem cells 3 IFN1@ (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 1870 100.00 rheumatoid arthritis 437 99.52 Arthritis 395 99.00 chemokine 254 98.96 Inflammation 1321 98.80 Multiple sclerosis 133 98.56 COX2 191 96.72 Crohn's disease 59 96.36 Neuropeptide 8 95.60 corticosteroid 25 95.56

Disease Link Frequency Relevance Heat Sprains And Strains 324 99.82 Guillain-barre Syndrome 9 99.70 Infection 830 99.68 Pneumonia 140 99.68 Proteinuria 88 99.68 Fever 35 99.64 Communicable Diseases 19 99.58 Disease 1069 99.56 Targeted Disruption 624 99.54 Chlamydia Infection 613 99.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, CD8+ T-cells in the elderly display significantly decreased ability to secrete interferon-gamma (IFN-?)

Localization (secrete) of IFN in T-cells

1) Confidence 0.78 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.14 Pain Relevance 0.07

In support of the postulated Th1 type response, intranasal immunization with H5N1 VLPs induced formation of memory T cells that could readily secrete IFN-?

Localization (secrete) of IFN in memory T cells associated with immunization

2) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.50 Pain Relevance 0

However, TLR4pre inhibited the releases of IL-10 and IFN-?

Localization (releases) of IFN

3) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.14 Pain Relevance 0.08

Alternatively, effector T-cells of the Th1 subset activates macrophages by CD154 – CD4+0 interactions and by secreting IFN-?.

Localization (secreting) of IFN in effector T-cells

4) Confidence 0.78 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.67 Pain Relevance 0.29

B super-repressor in HEp2 tumors leads to significant increase in cytotoxicity and secretion of IFN-?

Localization (secretion) of IFN associated with cancer

5) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.97 Pain Relevance 0.21

Lysis of hMSCs by untreated and IL-2 treated NK cells is inhibited by monocytes, however, the addition of monocytes induced significant secretion of IFN-?

Localization (secretion) of IFN in NK cells

6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.05 Pain Relevance 0

Increased NK cell cytotoxicity and augmented secretion of IFN-?

Localization (secretion) of IFN in NK cell

7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.49 Pain Relevance 0.15

Undifferentiated hMSCs were significantly more sensitive to lysis by IL-2 treated NK cells when compared to their differentiated counterparts (Fig. 5F), and triggered significant secretion of IFN-?

Localization (secretion) of IFN in NK cells

8) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.08 Pain Relevance 0

In ex vivo biopsy culture experiments, IL-15 is known to be induced by p31–43, and it also drives secretion of IFN-?

Localization (secretion) of IFN

9) Confidence 0.78 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.56 Pain Relevance 0.20

Activated CD4+ T cells enact a Th1 response, secreting IFN-?

Localization (secreting) of IFN in T cells

10) Confidence 0.78 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.33 Pain Relevance 0.18

In addition, MSCs and their chondrocyte progeny alike inhibited the secretion of proinflammatory cytokines IFN-?

Localization (secretion) of IFN in chondrocyte associated with cytokine

11) Confidence 0.78 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 1.04 Pain Relevance 0.40

Untreated or anti-CD16 mAb treated NK cells did not secrete IFN-?

Neg (not) Localization (secrete) of IFN in NK cells

12) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.17 Pain Relevance 0

when co-cultured with any of the stem cell populations; however, both IL-2 treated and IL-2 in combination with anti-CD16 mAb treated NK cells in the presence and absence of stem cells secreted significant levels of IFN-?

Localization (secreted) of IFN in stem cells

13) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.16 Pain Relevance 0

Indeed, stem cells triggered significant secretion of IFN-?

Localization (secretion) of IFN in stem cells

14) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.15 Pain Relevance 0

Lysis of hESCs, hiPSCs, hDPSCs, and hMSCs by untreated and IL-2 treated NK cells is inhibited by anti-CD16 antibody treatment, however, the same treatment induced significant secretion of IFN-?

Localization (secretion) of IFN in NK cells

15) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.21 Pain Relevance 0

In vitro stimulation of splenocytes harvested from vaccinated mice with HBsAg resulted in a cytokine response characterized by significant secretion of hallmark Th1 type cytokines such as IFN-?

Localization (secretion) of IFN associated with cytokine

16) Confidence 0.78 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2496893 Disease Relevance 0.58 Pain Relevance 0.15

in co-cultures with hMSCs, and further synergized with IL-2 or IL-2 and anti-CD16 mAb treated NK samples to increase the release of IFN-?

Localization (release) of IFN

17) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.06 Pain Relevance 0

As another means of measuring the T cell response elicited in the GM-CSF-adjuvanted and unadjuvanted vaccine groups, an ELISpot assay was used to enumerate the T cells in the blood of vaccinated animals secreting IFN-?

Localization (secreting) of IFN in T cell

18) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882341 Disease Relevance 0.12 Pain Relevance 0.04

These cells release IFN-?

Localization (release) of IFN

19) Confidence 0.78 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.74 Pain Relevance 0.27

Phase 2 consists of recognition of bacterial antigens by CD4 lymphocytes, which release mainly IL-2 and IFN-?

Localization (release) of IFN in lymphocytes

20) Confidence 0.78 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.49 Pain Relevance 0.28

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