INT170755

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 8.72
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
spleen 2
T cell 2
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 358 100.00 Very High Very High Very High
antagonist 15 98.72 Very High Very High Very High
fibrosis 44 96.88 Very High Very High Very High
psoriasis 53 96.08 Very High Very High Very High
Inflammation 211 94.28 High High
metalloproteinase 41 93.60 High High
chemokine 21 92.80 High High
Arthritis 168 91.12 High High
sodium channel 7 89.08 High High
agonist 55 85.56 High High
Disease Link Frequency Relevance Heat
Polyradiculoneuropathy 22 99.98 Very High Very High Very High
Diabetes Mellitus 6 98.52 Very High Very High Very High
Mycobacterial Infection 224 96.92 Very High Very High Very High
Pulmonary Fibrosis 23 96.88 Very High Very High Very High
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 1 96.40 Very High Very High Very High
Psoriasis 94 96.08 Very High Very High Very High
Guillain-barre Syndrome 3 96.08 Very High Very High Very High
Eczema 2 95.36 Very High Very High Very High
Immunization 13 95.32 Very High Very High Very High
Demyelinating Disease 5 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
might induce an increase of IFN-?
Spec (might) Positive_regulation (induce) of Positive_regulation (increase) of IFN
1) Confidence 0.67 Published 2008 Journal Arch Dermatol Res Section Body Doc Link PMC2254657 Disease Relevance 1.09 Pain Relevance 0.27
Increased induction of IFN- ?
Positive_regulation (Increased) of Positive_regulation (induction) of IFN
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.36 Pain Relevance 0.07
In all of the study groups, aqueous cytokine levels broadly showed three different patterns of response at 18 h postoperatively: those showing a high increase, IL-8, IL-6, IFN-?
Positive_regulation (high) of Positive_regulation (increase) of IFN associated with cytokine
3) Confidence 0.49 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779146 Disease Relevance 0 Pain Relevance 0.28
In all of the study groups, aqueous cytokine levels broadly showed three different patterns of response at 18 h postoperatively: those showing a high increase, IL-8, IL-6, IFN-?
Positive_regulation (showing) of Positive_regulation (increase) of IFN associated with cytokine
4) Confidence 0.49 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779146 Disease Relevance 0 Pain Relevance 0.28
Upon TCR ligation, they respond rapidly to secrete high levels of IFN-?
Positive_regulation (respond) of Positive_regulation (levels) of IFN
5) Confidence 0.49 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.22 Pain Relevance 0.10
This leads to a question of whether their apparent response to IFN-?
Positive_regulation (leads) of Spec (whether) Positive_regulation (response) of IFN
6) Confidence 0.49 Published 2000 Journal Respir Res Section Body Doc Link PMC59532 Disease Relevance 0.62 Pain Relevance 0.12
-triggered cytokine cascades in IP derives from the parallel elevations of IFN?
Positive_regulation (derives) of Positive_regulation (elevations) of IFN associated with polyradiculoneuropathy and cytokine
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2841649 Disease Relevance 1.23 Pain Relevance 0.37
In fact, many shared genes are readily identified as being immune related, such as immunity related GTPase, very large Ifn inducible GTPase, IL1?
Positive_regulation (inducible) of Positive_regulation (large) of Ifn
8) Confidence 0.49 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.42 Pain Relevance 0.17
We suggest that the HLXL-induced increase in IFN-?
Positive_regulation (induced) of Positive_regulation (increase) of IFN
9) Confidence 0.49 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958519 Disease Relevance 0.33 Pain Relevance 0.34
Upon stimulation with IFN-?
Positive_regulation (Upon) of Positive_regulation (stimulation) of IFN
10) Confidence 0.49 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.09 Pain Relevance 0
In the BCG-BCG subjects, a strong cellular immune response to PPD was elicited at 1-week post-vaccination, resulting in an increase in IFN?
Positive_regulation (resulting) of Positive_regulation (increase) of IFN
11) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.27 Pain Relevance 0.16
Rather, indeterminate results were due to high levels of IFN-?
Positive_regulation (due) of Positive_regulation (levels) of IFN
12) Confidence 0.49 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2279134 Disease Relevance 1.49 Pain Relevance 0.05
This hypothesis is consistent with our findings that splenectomy strongly inhibited (i) the BDL-induced increase in ROS generation by the circulating neutrophils (Fig. 7), (ii) the elevation of plasma IFN-?
Positive_regulation (increase) of Positive_regulation (elevation) of IFN in plasma
13) Confidence 0.49 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0.56 Pain Relevance 0.20
The aggrecan peptide induced the most pronounced profile of cytokines with induction of IL-17 and IFN-?
Positive_regulation (induced) of Positive_regulation (induction) of IFN associated with cytokine
14) Confidence 0.49 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 0.32 Pain Relevance 0.54
Juglone (1 µM) completely blocked the accumulation of I/P-induced IFN-?
Positive_regulation (accumulation) of Positive_regulation (accumulation) of IFN
15) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.23 Pain Relevance 0.17
The frequency of collagen -specific T cells in the spleen and the Th1/Th2 effector lineage of these cells were determined using cytokine ELISPOT by measuring collagen-induced IFN-?
Positive_regulation (measuring) of Positive_regulation (induced) of IFN in spleen associated with cytokine
16) Confidence 0.49 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0.08 Pain Relevance 0.09
Boosting BCG with MVA85A induces high levels of antigen specific IFN?
Positive_regulation (induces) of Positive_regulation (levels) of IFN
17) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.76 Pain Relevance 0
Indeed, chronic administration of BCG to mice leads to an increase in IFN-?
Positive_regulation (leads) of Positive_regulation (increase) of IFN
18) Confidence 0.45 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.13 Pain Relevance 0.16
In a mouse model of diabetes, HMGB1 upregulates CD40 expression and enhances IL-12 production by DCs, leading to natural killer (NK)T cell activation and subsequent NKT cell-dependent augmentation of IFN-?
Positive_regulation (leading) of Positive_regulation (augmentation) of IFN in T cell associated with diabetes mellitus
19) Confidence 0.01 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.53 Pain Relevance 0.26

General Comments

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