INT170757

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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 11.41
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr)
protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)
Anatomy Link Frequency
nasal 2
Cftr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Prostatitis 680 99.24 Very High Very High Very High
Chronic pancreatitis 34 99.04 Very High Very High Very High
Inflammation 311 98.56 Very High Very High Very High
cytokine 131 98.04 Very High Very High Very High
fibrosis 200 91.92 High High
Inflammatory response 20 69.76 Quite High
agonist 10 25.28 Quite Low
Pain 10 5.00 Very Low Very Low Very Low
pain pelvic 10 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Infection 230 99.80 Very High Very High Very High
Hyperplasia 20 99.60 Very High Very High Very High
Malignant Neoplastic Disease 9 99.44 Very High Very High Very High
Prostatitis 680 99.24 Very High Very High Very High
Pancreatitis 44 99.04 Very High Very High Very High
INFLAMMATION 331 98.56 Very High Very High Very High
Pulmonary Disease 28 97.72 Very High Very High Very High
Cancer 4 93.84 High High
Cystic Fibrosis 200 91.92 High High
Infection 51 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the present study also found enhanced CFTR and CAII expression in human hyperplasia tissues where inflammation was more prominent.
Positive_regulation (enhanced) of Gene_expression (expression) of CFTR associated with inflammation and hyperplasia
1) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 1.05 Pain Relevance 0.51
A prime example of an area in which this question should be asked is the role of CFTR dysfunction in increasing the risk for malignancy.
Positive_regulation (increasing) of Gene_expression (dysfunction) of CFTR associated with malignant neoplastic disease
2) Confidence 0.50 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.65 Pain Relevance 0.41
A rigorous search was conducted for other mutations in patients with one CFTR mutation, and CFTR function in nasal epithelia was assessed in vivo in patients with ICP [17].
Positive_regulation (conducted) of Gene_expression (mutation) of CFTR in nasal associated with chronic pancreatitis
3) Confidence 0.50 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 1.54 Pain Relevance 1.01
At the other end of the spectrum, 'mild' mutations may result in some production of functional CFTR protein at the apical membrane, with partial CFTR channel function, and are generally associated with pancreatic sufficiency and milder pulmonary disease.
Spec (may) Positive_regulation (result) of Gene_expression (production) of CFTR associated with pulmonary disease
4) Confidence 0.46 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 0.73 Pain Relevance 0.18
Since CFTR is involved in prostatic HCO3?
Positive_regulation (Since) of Gene_expression (involved) of CFTR
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.61 Pain Relevance 0.20
We suspect that considerable number of cases of bacterial infection would be gone unnoticed because of the enhanced CFTR-mediated HCO3?
Positive_regulation (gone) of Gene_expression (unnoticed) of CFTR-mediated associated with bacterial infection
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.87 Pain Relevance 0.23
What is the physiological significance of the upregulation of CFTR and the possible enhanced CFTR-mediated prostatic HCO3?
Spec (possible) Positive_regulation (enhanced) of Gene_expression (prostatic) of CFTR-mediated
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.80 Pain Relevance 0.46
More importantly, the present study has also demonstrated the physiological significance of the CFTR-mediated prostatic HCO3?
Positive_regulation (demonstrated) of Gene_expression (significance) of CFTR-mediated
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 1.00 Pain Relevance 0.43
The present findings also point to the possible role of the CFTR-mediated HCO3?
Positive_regulation (point) of Spec (possible) Gene_expression (role) of CFTR-mediated
9) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 1.01 Pain Relevance 0.45
, have been reported to upregulate CFTR expression [36], [37], [54].
Positive_regulation (upregulate) of Gene_expression (expression) of CFTR
10) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.64 Pain Relevance 0.30
secretion in humans was demonstrated by the upregulated expression of CFTR and CAII in human prostatitis tissues.


Positive_regulation (upregulated) of Gene_expression (expression) of CFTR associated with prostatitis
11) Confidence 0.34 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2998414 Disease Relevance 0.34 Pain Relevance 0.21
Together with the demonstrated CFTR and CAII upregulation, therefore enhanced prostatic HCO3?
Positive_regulation (enhanced) of Gene_expression (upregulation) of CFTR
12) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.59 Pain Relevance 0.18
Together with the demonstrated CFTR and CAII upregulation, therefore enhanced prostatic HCO3?
Positive_regulation (demonstrated) of Gene_expression (upregulation) of CFTR
13) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.58 Pain Relevance 0.17

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