INT170758

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.40
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr)
protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)
Anatomy Link Frequency
CPAE 2
Cftr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 5 98.60 Very High Very High Very High
fibrosis 44 96.84 Very High Very High Very High
adenocard 6 69.44 Quite High
Chronic pancreatitis 2 52.28 Quite High
fluoxetine 2 49.48 Quite Low
ischemia 12 5.00 Very Low Very Low Very Low
addiction 10 5.00 Very Low Very Low Very Low
Bile 7 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 54 99.98 Very High Very High Very High
Cancer 4 99.98 Very High Very High Very High
INFLAMMATION 5 98.60 Very High Very High Very High
Adenocarcinoma 3 98.04 Very High Very High Very High
Infection 1 98.04 Very High Very High Very High
Appetite Loss 2 97.48 Very High Very High Very High
Cystic Fibrosis 44 96.84 Very High Very High Very High
Malignant Neoplastic Disease 9 95.88 Very High Very High Very High
Digestive System Neoplasm 1 88.64 High High
Aspergillus Infection 2 57.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The key question is: are these neoplasms related to previously unrecognized functions of CFTR, or are they secondary to chronic inflammation, infection, or malnutrition, which might predispose to malignancy?
Positive_regulation (related) of Localization (functions) of CFTR associated with appetite loss, malignant neoplastic disease, inflammation, cancer and infection
1) Confidence 0.50 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.75 Pain Relevance 0.32
However, given the striking increase of studies suggesting capability of CFTR to conduct large anions when they are present on the intracellular side and where ATP hydrolysis can occur [44], one may suppose that, in certain physiological conditions, even normally ATP-impermeable Cl?
Positive_regulation (increase) of Localization (capability) of CFTR
2) Confidence 0.26 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.08 Pain Relevance 0.03
Heterologous expression of CFTR was shown to downregulate VSOR anion channel activity in CPAE and COS cells [116] as well as in HEK293T cells [117], but upregulate swelling-induced ATP release from C127/CFTR cells [58, 60].
Positive_regulation (induced) of Localization (release) of CFTR in CPAE associated with pressure and volume under development
3) Confidence 0.23 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.57 Pain Relevance 0

General Comments

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