INT170759

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.82
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr)
protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)
Cftr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Prostatitis 68 98.52 Very High Very High Very High
fibrosis 43 96.80 Very High Very High Very High
cytokine 14 89.04 High High
Inflammation 32 88.64 High High
Chronic pancreatitis 2 30.44 Quite Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostatitis 68 98.52 Very High Very High Very High
Cystic Fibrosis 43 96.80 Very High Very High Very High
Bacterial Infection 23 92.76 High High
Disease 13 90.80 High High
Infection 6 88.88 High High
INFLAMMATION 34 88.64 High High
Pancreatitis 8 86.08 High High
Exocrine Pancreatic Insufficiency 1 61.04 Quite High
Sinusitis 4 33.60 Quite Low
Nasal Polyps 1 32.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this limited screening, 37% of them had at least one CFTR mutation, and 11% had two identifiable CFTR mutations; 19% of the patients had the 5T allele in intron 8 of the gene for CFTR, a mutation that permits the formation of a small amount of normal CFTR but causes the vast majority of CFTR transcripts to lack exon 9 and be dysfunctional.
Positive_regulation (causes) of CFTR Binding (majority) of
1) Confidence 0.50 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 0.61 Pain Relevance 0.09
Interestingly, recent studies have indicated the possible involvement of defective CFTR-mediated HCO3?
Spec (possible) Positive_regulation (indicated) of CFTR-mediated Binding (involvement) of
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 1.21 Pain Relevance 0.52

General Comments

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