INT170768

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.61
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
hippocampus region 2
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 100.00 Very High Very High Very High
Hippocampus 1 97.22 Very High Very High Very High
antidepressant 42 94.38 High High
imagery 1 89.88 High High
Inflammation 20 76.20 Quite High
excitatory amino acid 1 70.68 Quite High
depression 45 63.00 Quite High
5HT 10 59.44 Quite High
agonist 5 55.24 Quite High
Inflammatory mediators 4 37.20 Quite Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 4 99.50 Very High Very High Very High
Neurodegenerative Disease 5 99.14 Very High Very High Very High
Stress 4 92.74 High High
Affective Disorder 3 92.02 High High
Frailty 2 90.90 High High
Glaucoma 2 84.04 Quite High
Bartter Syndrome 2 83.64 Quite High
Pressure And Volume Under Development 2 82.24 Quite High
Diabetes Mellitus 4 81.32 Quite High
INFLAMMATION 26 76.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relative amounts of GRalpha and GRbeta
Regulation (Relative) of Gene_expression (amounts) of GRbeta
1) Confidence 0.42 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.54 Pain Relevance 0.13
Relative amounts of GRalpha and GRbeta
Regulation (Relative) of Gene_expression (amounts) of GRalpha
2) Confidence 0.42 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.54 Pain Relevance 0.13
Chronic stress can also result in decreased neurogenesis (nerve cell growth).47 Brain imaging studies show structural brain changes (eg, atrophy or enlarged ventricles) in patients with mood disorders, and this may partly reflect stress-induced neurotoxicity or the inhibition of neurogenesis.44,48 Many antidepressant drugs have the effect of reducing neurotoxicity or enhancing neurogenesis.44 Similarly, agomelatine increases neurogenesis in the hippocampus region of the brain and may also have neuroprotective effects.49,50 The effects on neurogenesis and neurotoxicity are mediated in part by influencing glutamate release, glucocorticoid receptor gene expression, and various neurotrophic factors.51–55

Pharmacokinetic profile of agomelatine

Regulation (influencing) of Gene_expression (expression) of glucocorticoid receptor in hippocampus region associated with stress, glutamate, antidepressant, drug induced neurotoxicity, affective disorder, frailty, hippocampus, neurodegenerative disease and imagery
3) Confidence 0.07 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 1.54 Pain Relevance 0.32

General Comments

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