INT170769

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 66.36 Quite High
dexamethasone 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Lamotrigine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Gabapentin 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Affective Disorder 24 92.40 High High
Disease 3 90.52 High High
Asthma 11 87.48 High High
Occupational Lung Diseases 8 78.84 Quite High
Injury 20 74.60 Quite High
INFLAMMATION 13 66.36 Quite High
Post-traumatic Stress Disorder 3 65.76 Quite High
Manic Depressive Disorder 11 46.40 Quite Low
Aggression 1 19.84 Low Low
Stress 4 16.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The greater cortisol response and by implication the reduced GR mediated feedback inhibition in patients with a positive family history (in both the high and low emotional neglect groups) suggests that genetic factors may underlie this neuroendocrine finding.
Negative_regulation (reduced) of Negative_regulation (inhibition) of GR
1) Confidence 0.41 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.30 Pain Relevance 0
The initial observation of a dominant negative effect of GR?
Negative_regulation (observation) of Negative_regulation (effect) of GR
2) Confidence 0.16 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.65 Pain Relevance 0.06

General Comments

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