INT170772

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.05
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 81 99.30 Very High Very High Very High
Inflammation 99 73.36 Quite High
agonist 8 51.72 Quite High
Paracetamol 83 50.00 Quite Low
aspirin 48 50.00 Quite Low
anesthesia 2 46.52 Quite Low
Inflammatory mediators 8 33.68 Quite Low
cytokine 31 5.00 Very Low Very Low Very Low
Central nervous system 19 5.00 Very Low Very Low Very Low
Arthritis 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 81 99.30 Very High Very High Very High
Affective Disorder 24 94.68 High High
Occupational Lung Diseases 24 92.72 High High
Disease 45 89.76 High High
Glaucoma 3 80.52 Quite High
Bartter Syndrome 3 80.12 Quite High
Pressure And Volume Under Development 3 78.72 Quite High
Asthma 35 77.92 Quite High
Diabetes Mellitus 43 77.80 Quite High
INFLAMMATION 112 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A post-mortem study of bipolar patients showed decreased expression of GR mRNA (Perlman et al 2004; Webster et al 2002) and an exaggerated responses to the dex/CRH test in healthy first degree relatives of mood disorder patients has been found (Lauer et al 1998).
Negative_regulation (decreased) of Gene_expression (expression) of GR associated with affective disorder
1) Confidence 0.41 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.34 Pain Relevance 0
Assay of GR activity
Negative_regulation (Assay) of Gene_expression (activity) of GR
2) Confidence 0.35 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 0 Pain Relevance 0
It should be noted that resistance to GCs may result from the reduced expression of GR?
Negative_regulation (reduced) of Gene_expression (expression) of GR
3) Confidence 0.22 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.50 Pain Relevance 0.04
Our results suggest that the dominant negative effect of GR?
Negative_regulation (effect) of Neg (negative) Gene_expression (negative) of GR
4) Confidence 0.16 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.49 Pain Relevance 0.06
functions as a dominant negative inhibitor of GR?
Negative_regulation (inhibitor) of Neg (negative) Gene_expression (negative) of GR
5) Confidence 0.16 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.51 Pain Relevance 0.12
Assay of GR activity
Negative_regulation (Assay) of Gene_expression (activity) of GR
6) Confidence 0.11 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773744 Disease Relevance 0 Pain Relevance 0
Assay of GR activity
Negative_regulation (Assay) of Gene_expression (activity) of GR
7) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0
Recently, Neeck and colleagues, evaluating the expression of GR by immunoblot analysis, showed a higher expression of GR in untreated patients with RA in comparison with controls but a decreased GR expression in glucocorticoid-treated patients with RA in comparison with controls [202].
Negative_regulation (decreased) of Gene_expression (expression) of GR associated with rheumatoid arthritis
8) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.20 Pain Relevance 0.48

General Comments

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