INT170818

Context Info Confidence 0.44 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.93 Pain Relevance 1.02

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

Anatomy Link Frequency liver 1 vesicles 1 RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 13 93.92 agonist 30 91.44 Neurotransmitter 30 90.00 Catecholamine 9 89.32 Neuropeptide 238 78.48 beta blocker 3 40.16 Angina 2 10.16 Enkephalin 54 5.00 Inflammation 18 5.00 bradykinin 14 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 14 100.00 Cardiovascular Disease 2 100.00 Myocardial Infarction 35 99.00 Infarction 21 98.44 Cv Unclassified Under Development 12 93.92 Necrosis 1 92.88 Coronary Heart Disease 6 90.48 Death 2 87.92 Sepsis 44 86.60 Obesity 16 85.08

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There was no relationship between serum creatinine and either measure of RAS activation.

Localization (measure) of RAS

1) Confidence 0.44 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.49 Pain Relevance 0.03

The RAS in cardiovascular disease

Localization (disease) of RAS associated with cardiovascular disease

2) Confidence 0.28 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 1.08 Pain Relevance 0.05

LPL activity is mostly regulated posttranslationally via altered secretion from liver of LPL-modulating factors, including apolipoprotein C-III (Apoc3), apolipoprotein A-V (Apoa5), Angiopoietin-like protein 3 (Angptl3), and Angiopoietin-like protein 4 (Angptl4).

Localization (secretion) of A-V in liver associated with disorder of lipid metabolism

3) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.20

Interestingly, these secretory vesicles contained an extensive number of GTP nucleotide-binding proteins related to Rab, Rho, and Ras signaling molecules (50,51), together with SNARE-related proteins and annexins that are involved in trafficking and exocytosis of secretory vesicle components (52,53).

Localization (related) of Ras in vesicles

4) Confidence 0.01 Published 2010 Journal AAPS J Section Body Doc Link PMC2976990 Disease Relevance 0 Pain Relevance 0.74

General Comments

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