INT170823

Context Info Confidence 0.58 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.29

hydrolase activity, acting on glycosyl bonds (Gba2) plasma membrane (Gba2) lipid metabolic process (Gba2)

Anatomy Link Frequency bile 1 Gba2 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 53 100.00 sodium channel 6 72.16 fibrosis 30 55.08 anesthesia 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 9 98.04 Cystic Fibrosis 30 55.08 Disease 2 5.00 Liver Disease 2 5.00 Sprains And Strains 1 5.00 Dislocations 1 5.00 Lower Respiratory Tract Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In summary, in the widely studied cftr knockout mouse model (which clearly demonstrates intestinal pathology), the apical sodium dependent ileal bile acid transporter is expressed and functions at higher levels than in wild-type animals, with intermediate levels of IBAT expression and function in heterozygous cftr (+/-) mice.

Gene_expression (expressed) of bile acid in bile associated with targeted disruption and bile

1) Confidence 0.58 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.35 Pain Relevance 0.29

General Comments

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