INT170831

Context Info Confidence 0.58 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.11 Pain Relevance 0.86

transport (Slc10a2) nucleus (Slc10a2)

Anatomy Link Frequency bile 2 brush 2 Slc10a2 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 106 99.86 fibrosis 60 37.92 sodium channel 12 5.00 anesthesia 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Lower Respiratory Tract Infection 2 60.28 Targeted Disruption 18 50.00 Cystic Fibrosis 60 37.92 Disease 4 5.00 Liver Disease 4 5.00 Sprains And Strains 2 5.00 Dislocations 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Feeding of bile acids suppresses transcription of IBAT mRNA and reduces IBAT protein abundance; feeding of the bile acid binder cholestyramine has the opposite effect.

Negative_regulation (suppresses) of Transcription (transcription) of IBAT mRNA in bile associated with bile

1) Confidence 0.58 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.05 Pain Relevance 0.48

In hamsters, rats and mice, increases and decreases in bile acid absorption at the brush border membrane are mediated by an up- or down-regulation in IBAT gene transcription [33,34].

Negative_regulation (regulation) of Transcription (transcription) of IBAT gene in brush associated with bile

2) Confidence 0.37 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.06 Pain Relevance 0.38

General Comments

This test has worked.