INT170847

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.98
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccne2) cell cycle (Ccne2) cell division (Ccne2)
Anatomy Link Frequency
M cell 1
Ccne2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 7 75.92 Quite High
nMDA receptor 3 67.52 Quite High
agonist 3 64.96 Quite High
Action potential 1 57.44 Quite High
Dopamine 1 55.28 Quite High
antidepressant 5 51.96 Quite High
Substantia nigra 1 49.44 Quite Low
antagonist 5 46.64 Quite Low
Potency 4 44.12 Quite Low
cva 2 15.80 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 63 99.78 Very High Very High Very High
Myeloid Leukemia 1 96.68 Very High Very High Very High
Targeted Disruption 83 96.60 Very High Very High Very High
Leukemia 7 96.48 Very High Very High Very High
Hyperplasia 10 87.36 High High
Neuroblastoma 3 87.08 High High
Breast Cancer 5 81.60 Quite High
Cancer 186 80.80 Quite High
Lymphatic System Cancer 53 76.72 Quite High
Toxicity 6 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Ccne2 (cyclin E) and Cdk4 genes was validated by real time RT-PCR and the results agree with those of microarrays (Figure 5).
Gene_expression (Expression) of Ccne2
1) Confidence 0.58 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.68 Pain Relevance 0
Expression of Ccne2 (cyclin E) and Cdk4 genes was validated by real time RT-PCR and the results agree with those of microarrays (Figure 5).
Gene_expression (Expression) of cyclin E
2) Confidence 0.58 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.69 Pain Relevance 0
p27(KIP1) expression and inhibited cyclin E, cyclin D2 and CDK2 [122].
Gene_expression (expression) of cyclin E
3) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.75 Pain Relevance 0
Expression of p21 (panel E) is similar to that of cyclin E.
Gene_expression (Expression) of cyclin E
4) Confidence 0.02 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0 Pain Relevance 0
Donepezil reduces the number of cells in the S-G2/M phases of the cell cycle, increases the G0/G1 population, and reduces the expression of two cyclins of the G1/S and G2/M transitions, cyclin E and cyclin B, in parallel with an increase in the expression of the cell cycle inhibitor p21 (Sortino et al 2004).
Gene_expression (expression) of cyclin E
5) Confidence 0.02 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.33 Pain Relevance 0.21
Depsipeptide has been shown to induce differentiation, cause G1 and G2/M cell cycle arrest and apoptosis, increase expression of p21 and cyclin E, decrease expression of cyclin D1 and c-myc, and cause hypophosphorylation of Rb (Sandor et al 2000; Picardo et al 2004; Piekarz et al 2004; Piekarz and Bates 2004).
Gene_expression (expression) of cyclin E in M cell associated with apoptosis
6) Confidence 0.02 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 0.52 Pain Relevance 0

General Comments

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