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Context Info
Confidence 0.16
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.44
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Cdk4 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 1 69.60 Quite High
Chronic pancreatitis 1 68.92 Quite High
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 98.08 Very High Very High Very High
Pancreatic Cancer 26 94.48 High High
Hepatocellular Cancer 78 91.20 High High
Infection 24 81.28 Quite High
Retinoblastoma 2 77.52 Quite High
Apoptosis 43 71.52 Quite High
Diabetes Mellitus 1 70.16 Quite High
Cystic Fibrosis 1 69.60 Quite High
Pancreatitis 2 68.92 Quite High
Nicotine Addiction 1 66.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to explore the underlying molecular mechanism of CIAPIN1 affecting the cell cycle progression, we detected the expression of cell cycle-related molecules in AdSiCIAPIN1-infected SMMC-7721 cells, such as cyclinD1, p27, cdk2, cdk4 and p21 by western blot and found cdk2, cdk4 and p21 were not affected (data not show), except CyclyinD1 was downregulated and P27 was upregulated (Figure3F).
cdk4 Binding (cyclinD1) of
1) Confidence 0.16 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.01 Pain Relevance 0
In normal cells, p27 is sequestered and its activity gradually decreases as cells reach S phase, p27 preferentially binds cyclin D-cdk4, but lower levels of cdk4 (in TGF-?
cdk4 Binding (binds) of
2) Confidence 0.09 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.15 Pain Relevance 0
By binding to cyclin-dependent kinase 4, the p16 protein inhibits phosphorylation of various growth and regulation factors which control proliferation in the G1 period of the cell cycle.
cyclin-dependent kinase 4 Binding (binding) of
3) Confidence 0.01 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815837 Disease Relevance 1.27 Pain Relevance 0.10

General Comments

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