INT170852

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.62
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (IFI27) molecular_function (IFI27)
Anatomy Link Frequency
row 2
muscle 2
muscle fibers 2
epithelium 2
IFI27 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 1 98.28 Very High Very High Very High
pain pelvic 8 5.00 Very Low Very Low Very Low
endometriosis 7 5.00 Very Low Very Low Very Low
palliative 5 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 9 99.96 Very High Very High Very High
Cancer 421 99.66 Very High Very High Very High
Hypertrophy 70 99.50 Very High Very High Very High
Adenocarcinoma 77 99.40 Very High Very High Very High
Death 18 99.16 Very High Very High Very High
Apoptosis 80 98.72 Very High Very High Very High
Metastasis 61 97.88 Very High Very High Very High
Pancreatic Cancer 76 96.84 Very High Very High Very High
Gastrointestinal Neoplasms 5 96.64 Very High Very High Very High
Reprotox - General 1 7 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lu et al demonstrated that loss of p27 expression independently predicts a poor prognosis for patients with resectable pancreatic adenocarcinomas [24].
Negative_regulation (loss) of Gene_expression (expression) of p27 associated with adenocarcinoma
1) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 1.23 Pain Relevance 0
Recenty, the highly proliferative activity as measured by Ki-67 antigen has been shown to correlate with a reduced p27 expression in various tumors suggesting that decreased expression of p27 may play important role in the increased cell turnover [32].
Negative_regulation (reduced) of Gene_expression (expression) of p27 associated with cancer
2) Confidence 0.40 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.54 Pain Relevance 0
Recenty, the highly proliferative activity as measured by Ki-67 antigen has been shown to correlate with a reduced p27 expression in various tumors suggesting that decreased expression of p27 may play important role in the increased cell turnover [32].
Negative_regulation (decreased) of Gene_expression (expression) of p27 associated with cancer
3) Confidence 0.40 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.48 Pain Relevance 0
But it is not associated with cell cycle proteins. p27 expression is reduced in pancreatic adenocarcinomas and decreased protein levels of p27 may play a role in the differentiation of pancreatic cancer.



Negative_regulation (reduced) of Gene_expression (expression) of p27 associated with adenocarcinoma and pancreatic cancer
4) Confidence 0.40 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1208869 Disease Relevance 0.83 Pain Relevance 0
1 overexpression is more pronounced in metastatic and progressive ones. p27 expression is reduced in pancreatic adenocarcinomas and it may play a role in the differentiation of pancreatic cancer.
Negative_regulation (reduced) of Gene_expression (expression) of p27 associated with adenocarcinoma and pancreatic cancer
5) Confidence 0.40 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.86 Pain Relevance 0
Note that a lack of type I staining is characteristic for fast twitch fibers only (row 1), and a lack of p27 cytoplasmic expression is characteristic for the "resting" fast- and slow twitch fibers and fibers in "early transition" (rows 1, 2 and 5).
Negative_regulation (lack) of Gene_expression (expression) of p27 in row
6) Confidence 0.40 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.27 Pain Relevance 0
Quantitative evaluation of p27 expression
Negative_regulation (evaluation) of Gene_expression (expression) of p27
7) Confidence 0.40 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.26 Pain Relevance 0
Fibers in "advanced transition" (rows 3 and 4), and those undergoing degeneration (rows 6 and 7), are associated with cytoplasmic p27 expression.
Negative_regulation (cytoplasmic) of Gene_expression (expression) of p27
8) Confidence 0.40 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.06 Pain Relevance 0
Curiously, the remnants of p27 staining were confined to the nuclear envelope (arrows, Fig. 9, C and 9F; see also Fig. 10A), suggesting a degradation of p27 in the nuclear core, and/or a defect of p27 synthesis/transport.
Negative_regulation (defect) of Gene_expression (synthesis) of p27
9) Confidence 0.40 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.07 Pain Relevance 0
These data indicate that hypertrophy of muscle fibers may be accompanied by moderate p27 cytoplasmic expression.
Negative_regulation (accompanied) of Gene_expression (expression) of p27 in muscle fibers associated with hypertrophy
10) Confidence 0.40 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.17 Pain Relevance 0
p27 cytoplasmic expression and muscle abnormality
Negative_regulation (abnormality) of Gene_expression (expression) of p27 in muscle
11) Confidence 0.40 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.36 Pain Relevance 0
Moreover, a combined action of estrogens and progesterone, characteristic for the luteal phase, appears to cause a diminution of nuclear p27 expression in the epithelium of ectocervix and endometrium (Fig. 9, C and 9F).
Negative_regulation (diminution) of Gene_expression (expression) of p27 in epithelium
12) Confidence 0.40 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0 Pain Relevance 0
In endometrial carcinomas, loss of p27 expression may be involved in the tumor progression; however its down-regulation is not considered a predictor factor of adverse outcome for these neoplasms [11].
Negative_regulation (loss) of Gene_expression (expression) of p27 associated with cancer and endometrial cancer
13) Confidence 0.34 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 1.36 Pain Relevance 0
In tumours where 4/5 of the CIMP panel were hypermethylated, they found a decrease in the expression of nuclear p27 and p53, as well as reduced expression of COX2 and increased TGFBR2 mutations.
Negative_regulation (decrease) of Gene_expression (expression) of p27 associated with cancer and cox2
14) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.62 Pain Relevance 0.05
As one example, Guggulsterone, a plant-derived drug, caused cell-cycle arrest in S-phase by the suppression of cyclin D1 and cdc2 and increased cyclin-dependent kinase inhibitor p21 and p27 expression in a wide variety of human tumor cell types [37].
Negative_regulation (p21) of Gene_expression (expression) of p27 associated with cancer
15) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386551 Disease Relevance 0.76 Pain Relevance 0
As one example, Guggulsterone, a plant-derived drug, caused cell-cycle arrest in S-phase by the suppression of cyclin D1 and cdc2 and increased cyclin-dependent kinase inhibitor p21 and p27 expression in a wide variety of human tumor cell types [37].
Negative_regulation (p27) of Gene_expression (expression) of p27 associated with cancer
16) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386551 Disease Relevance 0.76 Pain Relevance 0

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