INT170853

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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 9.89
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CFD) extracellular space (CFD) extracellular region (CFD)
Anatomy Link Frequency
liver 4
muscle cells 2
adipocyte 2
CFD (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 15 99.92 Very High Very High Very High
fibrosis 165 98.44 Very High Very High Very High
Nicotine 79 91.08 High High
isoflurane 1 88.48 High High
Bile 6 86.40 High High
anesthesia 1 86.24 High High
antagonist 8 82.80 Quite High
Inflammation 109 68.72 Quite High
Thoracotomy 1 43.16 Quite Low
withdrawal 2 36.56 Quite Low
Disease Link Frequency Relevance Heat
Dengue 312 100.00 Very High Very High Very High
Renal Disease 15 100.00 Very High Very High Very High
Liver Disease 7 100.00 Very High Very High Very High
Obesity 7 99.76 Very High Very High Very High
Flavivirus Infection 240 99.52 Very High Very High Very High
Hypertrophy 10 99.34 Very High Very High Very High
Stress 28 99.24 Very High Very High Very High
Fibrosis 150 98.44 Very High Very High Very High
Disease 128 97.96 Very High Very High Very High
Focal Segmental Glomerulosclerosis 12 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the effectiveness of PFD in many cases depends on inherited genetic polymorphisms that increase the risk of developing advanced fibrosis in patients with established liver fibrosis [54].
Positive_regulation (effectiveness) of Gene_expression (effectiveness) of PFD in liver associated with fibrosis and internal fibrosis
1) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.21 Pain Relevance 0.31
Clinical trials using PFD for renal diseases
Positive_regulation (diseases) of Gene_expression (using) of PFD associated with renal disease
2) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.92 Pain Relevance 0.12
Clinical trials using PFD for liver diseases
Positive_regulation (diseases) of Gene_expression (using) of PFD in liver associated with liver disease
3) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.10 Pain Relevance 0.28
Optical BLI of transplanted DF+hESC-Ecs
Positive_regulation (transplanted) of Gene_expression (transplanted) of DF associated with imagery
4) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.08 Pain Relevance 0.70
During the convalescent phase, the mean factor D levels in the DF patients returned to that of DHF patients and control subjects (Figure 5B), suggesting that the levels of factor D in DF patients were reduced during acute dengue infection, limiting the rate of conversion of the C3bBB into the active C3 convertase, C3bBb, in these patients.
Positive_regulation (mean) of Gene_expression (levels) of factor D associated with flavivirus infection, dengue and infection
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.67 Pain Relevance 0
During the convalescent phase, the mean factor D levels in the DF patients returned to that of DHF patients and control subjects (Figure 5B), suggesting that the levels of factor D in DF patients were reduced during acute dengue infection, limiting the rate of conversion of the C3bBB into the active C3 convertase, C3bBb, in these patients.
Positive_regulation (returned) of Gene_expression (levels) of factor D associated with flavivirus infection, dengue and infection
6) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.74 Pain Relevance 0
In our study, levels of factor D in DF patients were lower than those in either DHF patients or healthy controls (Figure 5A), whereas during the convalescent phase, levels of factor D in DF patients were as high as those found in DHF patients during convalescent (Figure 5B).
Positive_regulation (lower) of Gene_expression (levels) of factor D associated with flavivirus infection and dengue
7) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.41 Pain Relevance 0
The expression of markers of adipocyte differentiation such as adipsin, aP2, and PPAR?
Positive_regulation (as) of Gene_expression (expression) of adipsin in adipocyte
8) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2605846 Disease Relevance 1.29 Pain Relevance 0
Conversely, levator ani from younger symptomatic patient (age 38) exhibited hypertrophy of muscle cells, accompanied by increased cytoplasmic p27 expression and manifestation of PFD.
Positive_regulation (increased) of Gene_expression (expression) of PFD in muscle cells associated with hypertrophy
9) Confidence 0.08 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.47 Pain Relevance 0

General Comments

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