INT170854

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 42
Disease Relevance 39.77
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CFD) extracellular space (CFD) extracellular region (CFD)
Anatomy Link Frequency
liver 4
plasma 3
adipose tissue 3
lung 2
Adipocytes 2
CFD (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 935 100.00 Very High Very High Very High
cytokine 134 100.00 Very High Very High Very High
antagonist 46 100.00 Very High Very High Very High
imagery 72 99.92 Very High Very High Very High
Nicotine 395 98.84 Very High Very High Very High
Inflammation 692 98.76 Very High Very High Very High
chemokine 34 98.16 Very High Very High Very High
Inflammatory marker 4 98.06 Very High Very High Very High
Bile 34 96.20 Very High Very High Very High
Spinal cord 1 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fibrosis 850 100.00 Very High Very High Very High
Internal Fibrosis 272 100.00 Very High Very High Very High
Polyostotic Fibrous Dysplasia 19 100.00 Very High Very High Very High
Poisoning 17 100.00 Very High Very High Very High
Obesity 374 99.98 Very High Very High Very High
Keloid Scars 153 99.96 Very High Very High Very High
Dengue 1040 99.84 Very High Very High Very High
Pulmonary Disease 146 99.80 Very High Very High Very High
Renal Disease 87 99.80 Very High Very High Very High
Liver Disease 37 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although PFD can produce spinal canal stenosis with consequent pathological implications, cervical cord contusions have never been reported before with this disorder.
Gene_expression (produce) of PFD in canal associated with pathologic constriction, polyostotic fibrous dysplasia and contusions
1) Confidence 0.68 Published 2006 Journal Head Face Med Section Body Doc Link PMC1562402 Disease Relevance 1.88 Pain Relevance 0.05
2 = 43.92, 4df, p < .001) and the Hosmer and Lemeshow test indicated good fit (?
Gene_expression (43.92) of 4df
2) Confidence 0.59 Published 2005 Journal Harm Reduct J Section Body Doc Link PMC550668 Disease Relevance 0.57 Pain Relevance 0
Previous data from our group [51] showed that PFD is an effective antifibrotic drug in two different experimental models of fibrosis (basal laminar deposits (BLD) and chronic intoxication by carbon tetrachloride (CCl4)), significantly decreasing levels of alanine aminotransferase (ALT), aspartate aminotransferase and alkaline phosphatase compared with saline-treated animals.
Gene_expression (decreasing) of PFD associated with fibrosis and poisoning
3) Confidence 0.36 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.75 Pain Relevance 0.21
Clinical trials using PFD for liver diseases
Gene_expression (using) of PFD in liver associated with liver disease
4) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.04 Pain Relevance 0.25
The antioxidant capacity of PFD produced a 28% and 30% reduction, respectively, in nitrite and malonyldealdehide concentrations in the bile duct ligation model, and 52% and 38% in the CCl4 model.
Gene_expression (produced) of PFD in bile duct associated with bile
5) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.61 Pain Relevance 0.16
After oral administration, PFD reaches its maximum levels in blood after 1 to 2 hours and is almost fully eliminated in urine after another 6 hours.
Gene_expression (reaches) of PFD in urine
6) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.40 Pain Relevance 0.04
In mice, Cho et al [4] observed that plasma PFD levels fell rapidly, with a mean residence time of 6.3 min, which agrees with the rapid disappearance of the drug.
Gene_expression (levels) of PFD in plasma
7) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.23 Pain Relevance 0
In vitro models of liver fibrosis and PFD
Gene_expression (models) of PFD in liver associated with fibrosis and internal fibrosis
8) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.25 Pain Relevance 0.27
It was also observed that PFD reduces AEs such as capsule contracture in mammary implants in an animal model, Gancedo et al. [68] observed a reduction in capsule thickness around submmamary tissue, along with a decrease in fibroblast-like cell proliferation, and recruitment and infiltration of inflammatory cells.
Gene_expression (reduces) of PFD in fibroblast associated with inflammation and contracture
9) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.41 Pain Relevance 0.11
Finally, PFD produced a modulation of apoptosis mediators in a chronic CsA-induced nephrotoxicity animal model.
Gene_expression (produced) of PFD associated with nephrotoxicity and apoptosis
10) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.79 Pain Relevance 0.10
Analysis of adverse events (AEs) revealed a correlation between PFD Cmax and the risk of AEs associated with the GI system, suggesting that food may reduce the risk of certain AEs associated with PFD administration, which may improve tolerability.
Gene_expression (administration) of PFD
11) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.24 Pain Relevance 0
Clinical trials using PFD for renal diseases
Gene_expression (using) of PFD associated with renal disease
12) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.91 Pain Relevance 0.11
Furthermore, the effectiveness of PFD in many cases depends on inherited genetic polymorphisms that increase the risk of developing advanced fibrosis in patients with established liver fibrosis [54].
Gene_expression (effectiveness) of PFD in liver associated with fibrosis and internal fibrosis
13) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.21 Pain Relevance 0.31
By the end of the 5 min infusion, PFD and its two main metabolites, hydroxypirfenidone and carboxypirfenidone, were detected, and mean peak plasma concentration of PFD was 182.5 ?
Gene_expression (detected) of PFD in plasma
14) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.28 Pain Relevance 0
It has been shown that PFD reduces keloid formation in an animal model.
Gene_expression (reduces) of PFD associated with keloid scars
15) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.61 Pain Relevance 0.08
Additional proof of reduction in ECM by PFD was observed in mouse mesangial cells, in which PFD decreased TGF-?
Gene_expression (decreased) of PFD in mesangial cells
16) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.71 Pain Relevance 0.15
Clinical trials using PFD for lung disease
Gene_expression (using) of PFD in lung associated with pulmonary disease
17) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.53 Pain Relevance 0.36
In vitro models of liver fibrosis and PFD
Gene_expression (fibrosis) of PFD in liver associated with fibrosis and internal fibrosis
18) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.24 Pain Relevance 0.26
production by purified T cells, and PFD had no effect on the suppressive properties of naturally occurring regulatory T cells [25] In addition, the antifibrotic effect of PFD may be mediated through inhibition of heat shock protein 47, a collagen-specific molecular chaperone, with a resultant reduction in collagen synthesis in lung fibrosis [26].


Gene_expression (production) of PFD in lung associated with fibrosis, shock and pulmonary fibrosis
19) Confidence 0.28 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.33 Pain Relevance 0.51
These data suggest that during acute dengue infection, the patients who are more capable of modulating their levels of factor D will exhibit the mild disease phenotype DF.
Gene_expression (levels) of factor D associated with dengue, disease and infection
20) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.64 Pain Relevance 0

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