INT17086

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Context Info
Confidence 0.47
First Reported 1986
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 84
Total Number 88
Disease Relevance 122.28
Pain Relevance 6.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
plasma 8
blood 4
body 3
respiratory 2
liver 1
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 97 100.00 Very High Very High Very High
alcohol 145 99.60 Very High Very High Very High
Restless leg syndrome 5 99.36 Very High Very High Very High
Inflammation 194 98.88 Very High Very High Very High
Pain 341 97.76 Very High Very High Very High
rheumatoid arthritis 204 93.72 High High
headache 16 92.28 High High
Bile 67 91.96 High High
Migraine 7 91.92 High High
anesthesia 6 86.56 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 5825 100.00 Very High Very High Very High
Diabetes Mellitus 1290 100.00 Very High Very High Very High
Cardiovascular Disease 1097 100.00 Very High Very High Very High
Hypertriglyceridemia 375 100.00 Very High Very High Very High
Disease 365 100.00 Very High Very High Very High
Obesity 326 100.00 Very High Very High Very High
Nicotine Addiction 274 100.00 Very High Very High Very High
Myocardial Infarction 245 100.00 Very High Very High Very High
Hyperlipidemia 144 100.00 Very High Very High Very High
Hypertension 118 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In female non-diabetic population, TC, LDL-C, non-HDL-C and TG showed significant association with CVD event with the same discrimination in full adjusted analysis.
HDL Binding (association) of associated with hypertriglyceridemia, cardiovascular disease, diabetes mellitus and disorder of lipid metabolism
1) Confidence 0.47 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.58 Pain Relevance 0
HDL-C association much.
HDL Binding (association) of associated with disorder of lipid metabolism
2) Confidence 0.47 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 0.95 Pain Relevance 0.15
Each of several chronic diseases, i.e. diabetes, cardiovascular diseases (myocardial infarction, angina pectoris, and stroke), pulmonary diseases (asthma, rhinitis, and chronic bronchitis) was negatively associated with HDL-C.
HDL Binding (associated) of associated with angina, pulmonary disease, stroke, diabetes mellitus, bronchitis, asthma, rhinitis, cardiovascular disease, disorder of lipid metabolism, chronic disease and myocardial infarction
3) Confidence 0.47 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 2.23 Pain Relevance 0.10
Association of HDL-C with sickle cell disease clinical history
HDL Binding (Association) of associated with sickle cell anemia and disorder of lipid metabolism
4) Confidence 0.47 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2940866 Disease Relevance 2.35 Pain Relevance 0.08
In conclusion, there seems to be a consistent association between HDL-C and self-reported health, as observed in many age groups and in both sexes.
HDL Binding (association) of associated with disorder of lipid metabolism
5) Confidence 0.47 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 0.74 Pain Relevance 0.15
It cannot be ruled out that some covariates, such as diabetes, physical activity and intake frequency of alcohol, might be causally associated with HDL-C.
HDL Spec (might) Binding (associated) of associated with diabetes mellitus, disorder of lipid metabolism and alcohol
6) Confidence 0.47 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 0.83 Pain Relevance 0.08
Interestingly, the positive association between SRH and HDL-C was found also within groups of subjects with a history of chronic diseases (results not shown).
HDL Binding (association) of associated with chronic disease and disorder of lipid metabolism
7) Confidence 0.36 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 2.19 Pain Relevance 0.09
It would appear that many of the single-factor associations with SRH could be explained by relations to a third factor, and that although HDL-C might serve as a health marker, the association between SRH and HDL-C might be weakened and possibly eliminated when adjusting for potential confounders such as gender, age, chronic disease, body mass index, physical activity, and social factors.
HDL Spec (might) Binding (association) of in body associated with obesity, chronic disease and disorder of lipid metabolism
8) Confidence 0.36 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 0.56 Pain Relevance 0
This analysis showed that only HDL-c and TG/HDL-c show statistically significant frequency differences between the fourth and first quartiles, and that the difference was larger for TG/HDL-c.
HDL Binding (larger) of associated with disorder of lipid metabolism
9) Confidence 0.36 Published 2008 Journal Clinics Section Body Doc Link PMC2664115 Disease Relevance 1.68 Pain Relevance 0
A highly significant association between HDL-C and SRH persisted within both the “low” and the “high” lipid groups.
HDL Binding (association) of associated with disorder of lipid metabolism
10) Confidence 0.36 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 0.61 Pain Relevance 0
Thus, it would appear that the presence of chronic illnesses only partially explains the association between HDL-C and SRH.


HDL Binding (association) of associated with disorder of lipid metabolism and chronic disease
11) Confidence 0.36 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 2.09 Pain Relevance 0.08
To identify possible associations between HDL-C levels and clinical characteristics in SCD we assessed medical history from patients' records, including prevalence of stroke, number of hospitalizations, painful episodes, VOE, infection, pneumonia, priapism, splenomegaly, splenic sequestration, leg ulcers, cardiac abnormalities, respiratory insufficiency and cholelithiasis.
HDL Binding (associations) of in respiratory associated with sickle cell anemia, pain, leg ulcer, splenomegaly, stroke, pneumonia, gallstones, cardiovascular disorder under development, infection, reprotox - general 2, respiratory failure and disorder of lipid metabolism
12) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2940866 Disease Relevance 1.58 Pain Relevance 0.14
Associations between SRH and HDL-C, adjusting for covariates
HDL Binding (Associations) of associated with disorder of lipid metabolism
13) Confidence 0.36 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 1.18 Pain Relevance 0.03
The present finding that the strength of the association between SRH and HDL-C was somewhat attenuated when controlling for many of these factors would seem in support of this contention.
HDL Binding (association) of associated with disorder of lipid metabolism
14) Confidence 0.36 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 0.83 Pain Relevance 0.10
In view of the positive association between HDL-C and self rated health, it might be questioned whether the subjects knew their serum lipid values, and the effect they might have on their health, and thereby influence their health rating.
HDL Binding (association) of associated with disorder of lipid metabolism
15) Confidence 0.36 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 1.52 Pain Relevance 0.06
Inclusion of a number of factors in the analyses had a moderating effect on the association between SRH and HDL-C, but did not eliminate the relationship.
HDL Binding (association) of associated with disorder of lipid metabolism
16) Confidence 0.36 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 0.84 Pain Relevance 0.18
The non significant association of LDL-C and non-HDL-C in diabetic women with incident CVD might be partly attributed to the limited statistical power.
HDL Binding (association) of associated with cardiovascular disease, diabetes mellitus and disorder of lipid metabolism
17) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.78 Pain Relevance 0
In non-diabetic women, HDL-C did not show any association with CVD risk in both models.
HDL Binding (association) of associated with cardiovascular disease, diabetes mellitus and disorder of lipid metabolism
18) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.82 Pain Relevance 0
In this study, among the diabetic population, HDL-C in both genders was not associated with incident CVD, although there was significant protective effect of HDL-C in non-diabetic men.
HDL Binding (associated) of associated with cardiovascular disease, diabetes mellitus and disorder of lipid metabolism
19) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.50 Pain Relevance 0
In the current study, TG/HDL-C did not show any association with CVD in both genders of diabetic population and also in non-diabetic women.
HDL Binding (association) of associated with hypertriglyceridemia, diabetes mellitus, cardiovascular disease and disorder of lipid metabolism
20) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.13 Pain Relevance 0

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