INT170899

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Context Info
Confidence 0.19
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.46
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
femoral artery 2
nerve 2
brain 2
C8-B4 2
hearts 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 81 99.86 Very High Very High Very High
antidepressant 35 99.78 Very High Very High Very High
Glutamate 8 99.74 Very High Very High Very High
long-term potentiation 74 99.22 Very High Very High Very High
amygdala 126 99.14 Very High Very High Very High
qutenza 79 98.72 Very High Very High Very High
GABAergic 14 98.12 Very High Very High Very High
conotoxin 3 98.12 Very High Very High Very High
Cannabinoid receptor 16 97.44 Very High Very High Very High
Cannabinoid 121 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 226 100.00 Very High Very High Very High
Cerebral Edema 10 100.00 Very High Very High Very High
Diabetes Mellitus 155 99.84 Very High Very High Very High
Targeted Disruption 83 98.92 Very High Very High Very High
Hyperglycemia 18 97.68 Very High Very High Very High
Apoptosis 33 97.00 Very High Very High Very High
Breast Cancer 70 95.80 Very High Very High Very High
Heart Rate Under Development 6 95.36 Very High Very High Very High
Death 27 93.72 High High
Infection 31 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, while wortmannin (WT) inhibited both the activation of Akt (Fig. 4B, top) and SphK1 (Fig. 4B, bottom) induced by DHT, the SphK1 inhibitor SKI-2 did not impact Akt phosphorylation (Fig. 4B, top).
Negative_regulation (inhibited) of Positive_regulation (activation) of Fig
1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0.03
Remarkably, coinfusion of Ex4 into the brain under hyperglycemic conditions abolished the increase in femoral artery blood flow (Fig. 3A and C).
Negative_regulation (abolished) of Positive_regulation (increase) of Fig in femoral artery associated with agonist
2) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.42 Pain Relevance 0.24
Why do pre-applications of antidepressants lead to a reduction in P2X4 receptor responses in activated C8-B4 cells (Fig. 12), even though these drugs do not inhibit P2X4 receptors directly (Fig. 11)?
Negative_regulation (reduction) of Positive_regulation (activated) of Fig in C8-B4 associated with antidepressant
3) Confidence 0.18 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.50
Since we could not detect an involvement of GABAergic interneurons in the capsaicin-induced effect on LA-LTP, the release of glutamate seems to be reduced by CB1 activation (Fig. 8).
Negative_regulation (reduced) of Positive_regulation (activation) of Fig in interneurons associated with glutamate, qutenza, gabaergic, long-term potentiation and amygdala
4) Confidence 0.17 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.31
Correspondingly, combination therapy significantly prevented tPA-induced brain edema at 18 h after reperfusion (Fig. 3B).
Negative_regulation (prevented) of Positive_regulation (induced) of Fig in brain associated with cerebral edema
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997776 Disease Relevance 0.74 Pain Relevance 0.16
N202.1A cells showed a dose-dependent reduction in Akt activation (Fig. 6D).
Negative_regulation (reduction) of Positive_regulation (activation) of Fig
6) Confidence 0.10 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.48 Pain Relevance 0.24
B DNA binding decreased with increasing concentrations of NAPQI (Fig. 1C) and DNCB (Fig. 1D).
Negative_regulation (decreased) of Positive_regulation (increasing) of Fig
7) Confidence 0.09 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.13 Pain Relevance 0.13
B DNA binding decreased with increasing concentrations of NAPQI (Fig. 1C) and DNCB (Fig. 1D).
Negative_regulation (decreased) of Positive_regulation (increasing) of Fig
8) Confidence 0.09 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.12 Pain Relevance 0.13
As expected, CRIF1 overexpression reduced accumulation of both exogenous NRF2 as well as an NRF2 target gene-encoded protein HO-1 (Fig. 3A).
Negative_regulation (reduced) of Positive_regulation (accumulation) of Fig
9) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Caspase-3 activation (Fig. 8A) was significantly reduced in diabetic RAGE RAGE-KO, Tg DN PPET RAGE, and Tg DN MSR RAGE hearts versus diabetic wild-type hearts after I/R (P < 0.05).
Negative_regulation (reduced) of Positive_regulation (activation) of Fig in hearts associated with targeted disruption and diabetes mellitus
10) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 2.45 Pain Relevance 0
We observed a decrease in Akt activation in THC-treated MMTV-neu tumors (Fig. 5B) as well as diminished levels of phosphorylated S6 ribosomal protein [a read-out for activation of the Akt/mammalian target of rapamycin (mTOR) pathway [12]] (Fig. 5C).
Negative_regulation (decrease) of Positive_regulation (activation) of Fig associated with cancer
11) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.58 Pain Relevance 0.22
Fig. 2 showed that C.jejuni-induced IL-12p40 (Fig. 2A) and IL-6 (Fig. 2B) mRNA accumulation was strongly reduced in Bay 11-7085-treated BMDC compared to untreated cells.
Negative_regulation (reduced) of Positive_regulation (accumulation) of Fig
12) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760752 Disease Relevance 0.22 Pain Relevance 0.04
1 of MCE with LPS strongly suppressed the induction of COX-2 (Fig. 3).


Negative_regulation (suppressed) of Positive_regulation (induction) of Fig
13) Confidence 0.05 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC1978242 Disease Relevance 0.09 Pain Relevance 0.04
Both drugs virtually abolished the electrical responses to EFS (Fig. 3A, B), suggesting that the EFS-elicited SMD requires activation of postganglionic nerve terminals and release of a neurotransmitter substance.
Negative_regulation (abolished) of Positive_regulation (responses) of Fig in nerve associated with neurotransmitter
14) Confidence 0.04 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0.06 Pain Relevance 0.37
Results from this study further indicated that PPAR agonists could reduce c-jun activation (Fig. 6).
Negative_regulation (reduce) of Positive_regulation (activation) of Fig associated with agonist
15) Confidence 0.03 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.17 Pain Relevance 0.16
Removal of extracellular calcium or incubation with the intracellular calcium chelator BAPTA-AM for 30 min prior to BDNF stimulation blocked the induction of gene expression responses (Fig. 4A).
Negative_regulation (blocked) of Positive_regulation (induction) of Fig
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0 Pain Relevance 0.12

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