INT170900

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Context Info
Confidence 0.20
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.44
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
lung 4
uterus 2
retina 2
bile 2
upper 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 16 100.00 Very High Very High Very High
fibrosis 38 98.54 Very High Very High Very High
gABA 20 98.48 Very High Very High Very High
agonist 72 96.08 Very High Very High Very High
antagonist 61 82.72 Quite High
Bioavailability 5 73.52 Quite High
Inflammation 106 68.20 Quite High
corticosteroid 2 32.56 Quite Low
Potency 11 29.08 Quite Low
Spinal cord 6 29.00 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 65 100.00 Very High Very High Very High
Pulmonary Disease 42 100.00 Very High Very High Very High
Pseudomonas Infection 36 100.00 Very High Very High Very High
Cystic Fibrosis 38 98.54 Very High Very High Very High
Targeted Disruption 210 90.16 High High
Alzheimer's Dementia 163 86.68 High High
Diabetic Retinopathy 7 84.80 Quite High
Death 43 81.76 Quite High
Neurodegenerative Disease 21 77.76 Quite High
Amyloid Plaque 38 70.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When qRT-PCR was used to measure the expression of three target genes in mouse uterus, both Smad7 and Tmem55a were also up-regulated under activation (Fig. 3A).
Regulation (regulated) of Positive_regulation (activation) of Fig in uterus
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
To determine the effect of the RAS activation in the diabetic retina (Fig. 1) on visual function, we performed ERG analyses (Fig. 2).
Spec (determine) Regulation (effect) of Positive_regulation (activation) of Fig in retina associated with diabetes mellitus
2) Confidence 0.19 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.88 Pain Relevance 0
Especially the upper right positions in the control dataset and more pronounced in the LPS-treated dataset display an inverse regulation of the gene clusters following luteolin stimulation (Fig. 2A, white circles).
Regulation (regulation) of Positive_regulation (stimulation) of Fig in upper
3) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0 Pain Relevance 0
The result shows that FK506 treatment did not alter PrPSc accumulation (Fig. 4B), a result consistent with our hypothesis that CaN activation is a downstream event of prion replication.
Neg (not) Regulation (alter) of Positive_regulation (accumulation) of Fig
4) Confidence 0.09 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.19 Pain Relevance 0
These results indicate that intestinal Fgf15 plays a crucial role in regulating hepatic bile acid synthesis at postnatal stages by activating hepatic Fgfr4 in an endocrine manner (Table 1 and Fig. 2) (Inagaki et al. 2005).
Regulation (regulating) of Positive_regulation (activating) of Fig in bile associated with bile
5) Confidence 0.07 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.25 Pain Relevance 0.26
We have standardized the PLGA-PEG based PS341 delivery to CF (Cftr-/-, FABP-CFTR gut corrected) murine lungs based on its ability to control Pa-LPS induced lung disease (Fig 8, 9, 10, 11 and 12) and inhibition of proteasomal activity (Fig 3).
Regulation (control) of Positive_regulation (induced) of Fig in lung associated with fibrosis, pseudomonas infection and pulmonary disease
6) Confidence 0.07 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.64 Pain Relevance 0.20
We have standardized the PLGA-PEG based PS341 delivery to CF (Cftr-/-, FABP-CFTR gut corrected) murine lungs based on its ability to control Pa-LPS induced lung disease (Fig 8, 9, 10, 11 and 12) and inhibition of proteasomal activity (Fig 3).
Regulation (control) of Positive_regulation (induced) of Fig in lung associated with fibrosis, pseudomonas infection and pulmonary disease
7) Confidence 0.06 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.64 Pain Relevance 0.20
is responsible for its extracellular accumulation (Fig. 2).
Regulation (responsible) of Positive_regulation (accumulation) of Fig
8) Confidence 0.05 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.69 Pain Relevance 0
It is important to note that this agent also had no inhibitory effect on c-jun activation (Fig. 6).
Neg (no) Regulation (effect) of Positive_regulation (activation) of Fig
9) Confidence 0.03 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.14 Pain Relevance 0.12
Although GABA binds in the GABAB1 VFT, it is now well demonstrated that the GABAB2 HD is responsible for G-protein activation (Fig. 1).
Regulation (responsible) of Positive_regulation (activation) of Fig associated with gaba
10) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.17
caused a significant time-dependent increase in COX-2 Luciferase reporter activity (Fig, 4A; P < 0.05) and mRNA expression (Fig. 4B; P < 0.05) which peaked at 4–6 h.
Regulation (dependent) of Positive_regulation (increase) of Fig
11) Confidence 0.02 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.30

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