INT170922

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 59
Total Number 59
Disease Relevance 28.45
Pain Relevance 6.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
cardiomyocytes 1
luteal cells 1
theca cells 1
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 737 100.00 Very High Very High Very High
Potency 77 99.34 Very High Very High Very High
Nicotine 3 98.72 Very High Very High Very High
cytokine 16 97.36 Very High Very High Very High
Inflammation 259 95.16 Very High Very High Very High
cINOD 185 94.80 High High
ischemia 62 92.20 High High
cva 36 91.68 High High
Inflammatory response 46 84.96 Quite High
imagery 11 84.20 Quite High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 84 99.98 Very High Very High Very High
Atherosclerosis 49 99.76 Very High Very High Very High
Diabetes Mellitus 116 99.56 Very High Very High Very High
Apoptosis 851 99.36 Very High Very High Very High
Targeted Disruption 86 98.72 Very High Very High Very High
Toxicity 83 98.36 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

26 98.08 Very High Very High Very High
Brain Hemorrhage 12 97.88 Very High Very High Very High
Metabolic Syndrome 45 97.60 Very High Very High Very High
Obesity 279 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ligands enhance binding of PPAR?
PPAR Binding (binding) of
1) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.39 Pain Relevance 0
The latter effect, however, was not associated with induced PPAR?
PPAR Binding (associated) of
2) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.21 Pain Relevance 0
This hypothesis is also supported by an in vitro study in cardiomyocytes by Sandra and colleagues [45] which demonstrated that cardiac hypertrophy associated with the treatment of PPAR-?
PPAR Binding (associated) of in cardiomyocytes associated with coronary heart disease
3) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.85 Pain Relevance 0.10
directly bind to PPAR response elements (PPREs) because the two receptors share
PPAR Binding (bind) of
4) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.17 Pain Relevance 0
Reported data indicate that ligand-activated PPAR?
PPAR Binding (ligand) of
5) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.85 Pain Relevance 0.04
Consistent with reduced Bad translocation to mitochondria, mitochondrial membrane potential is restored and release of cytochrome C and Diablo is suppressed in H2O2-treated cells supplemented with PPAR?
PPAR Binding (supplemented) of
6) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.92 Pain Relevance 0.26
Ligand-activated PPAR?
PPAR Binding (Ligand) of
7) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.66 Pain Relevance 0.09
It is unclear whether ligand-activated PPAR?
PPAR Binding (ligand) of
8) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.16 Pain Relevance 0.07
binding to the PPRE region by chromatin immunoprecipitation reveals that PPAR?
PPAR Binding (binding) of
9) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.39 Pain Relevance 0
Since these are agents used clinically for other purposes, it is important to determine whether interaction of these agents with PPARs could modulate atherogenesis in a positive or negative manner.
PPAR Binding (interaction) of associated with atherosclerosis
10) Confidence 0.35 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.70 Pain Relevance 0.51
activator in an in vitro system, the involvement of PPAR?
PPAR Binding (involvement) of
11) Confidence 0.34 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.54 Pain Relevance 0.20
First, synthetic PGI2 analogs including carbaprostacyclin (cPGI2) and iloprost were reported to bind PPAR?
PPAR Binding (bind) of
12) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.92 Pain Relevance 0
, (2) identical cis-regulatory element motif that is recognized by PPAR?
PPAR Binding (recognized) of
13) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.91 Pain Relevance 0.03
Some compounds such as carbaprostacyclin bind and activate PPAR?
PPAR Binding (bind) of
14) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.13 Pain Relevance 0.19
are mediated through enhanced binding of PPAR to the promoter of 14-3-3?
PPAR Binding (binding) of
15) Confidence 0.33 Published 2010 Journal PPAR Research Section Abstract Doc Link PMC2938460 Disease Relevance 0.53 Pain Relevance 0.05
For example, peroxisomal proliferation/PPAR agonists could be recognized with one single marker gene.
PPAR Binding (recognized) of associated with agonist
16) Confidence 0.33 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1277117 Disease Relevance 0.33 Pain Relevance 0.05
L RT2 validated PCR primer set for PPAR?
PPAR Binding (primer) of
17) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0 Pain Relevance 0.04
possible physiological role for PPAR?
PPAR Binding (role) of
18) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.21 Pain Relevance 0.03
However, in addition to PPAR?
PPAR Binding (addition) of
19) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.14 Pain Relevance 0
may be essential for normal cardiac development, but that treatment with exogenous PPAR-?
PPAR Binding (exogenous) of
20) Confidence 0.32 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.89 Pain Relevance 0.25

General Comments

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