INT170927

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Context Info
Confidence 0.54
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 13.58
Pain Relevance 5.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
chondrocytes 1
somatic cell 1
liver 1
colon 1
oocyte 1
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 400 100.00 Very High Very High Very High
cINOD 74 99.22 Very High Very High Very High
antagonist 35 99.12 Very High Very High Very High
Potency 53 98.12 Very High Very High Very High
Inflammation 165 98.00 Very High Very High Very High
imagery 6 91.72 High High
adenocard 5 90.76 High High
Inflammatory mediators 2 84.88 Quite High
Intractable pain 1 76.80 Quite High
fibrosis 18 73.84 Quite High
Disease Link Frequency Relevance Heat
Injury 20 100.00 Very High Very High Very High
Apoptosis 355 99.92 Very High Very High Very High
Targeted Disruption 40 99.88 Very High Very High Very High
Colon Cancer 11 99.62 Very High Very High Very High
Hepatocellular Cancer 26 98.72 Very High Very High Very High
Hypoxia 30 98.60 Very High Very High Very High
Toxicity 12 98.52 Very High Very High Very High
Chronic Hepatitis 1 98.20 Very High Very High Very High
INFLAMMATION 212 98.00 Very High Very High Very High
Obesity 115 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in colorectal cancer cells promotes cell proliferation [26, 27] and NSAIDs induce colon cancer cell apoptosis by suppressing PPAR?
Negative_regulation (suppressing) of PPAR in colon associated with colon cancer, cinod and apoptosis
1) Confidence 0.54 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.20 Pain Relevance 0.53
adipogenic effect, reduced PPAR?
Negative_regulation (reduced) of PPAR
2) Confidence 0.51 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.19 Pain Relevance 0
Studies using cardiac-specific deletion revealed that loss of PPAR-?
Negative_regulation (loss) of PPAR
3) Confidence 0.51 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.46 Pain Relevance 0.14
Results from our laboratories have shown that sulindac sulfide and indomethacin suppress PPAR?
Negative_regulation (suppress) of PPAR
4) Confidence 0.48 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.26 Pain Relevance 0.52
Sulindac and indomethacin induce HUVEC apoptosis by suppressing PPAR?
Negative_regulation (suppressing) of PPAR associated with apoptosis
5) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.41 Pain Relevance 0.67
The protective effect of PPAR?
Negative_regulation (effect) of PPAR
6) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.51 Pain Relevance 0.04
expression levels of PPAR?
Negative_regulation (levels) of PPAR
7) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0 Pain Relevance 0.05
Thus increased sodium reabsorption by chronic PD168 treatment found in the present study could be a direct effect of PPAR-?
Negative_regulation (effect) of PPAR
8) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.82 Pain Relevance 0.03
In contrast, there are some studies which suggest a protective effect of PPAR-?
Negative_regulation (effect) of PPAR
9) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.40 Pain Relevance 0.20
Nevertheless, there are some studies which support a direct effect of PPAR-?
Negative_regulation (effect) of PPAR
10) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.49 Pain Relevance 0.15
These data were consistent with the inhibitory effect of PPAR?
Negative_regulation (effect) of PPAR
11) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0.07 Pain Relevance 0.30
PGI2 overproduction via Ad-COPI gene transfer was shown to reduce renal I/R injury through PPAR?
Negative_regulation (reduce) of PPAR associated with injury
12) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.99 Pain Relevance 0.13
Polyunsaturated fatty acid-induced PPAR activation inhibits NF?
Negative_regulation (inhibits) of PPAR
13) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2796387 Disease Relevance 1.22 Pain Relevance 0.97
as

ICI was previously shown to inhibit the action of the selective PPAR?

Negative_regulation (inhibit) of PPAR
14) Confidence 0.33 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.46 Pain Relevance 0.05
agonist rosiglitazone and was affected neither by blockade of PPAR?
Negative_regulation (blockade) of PPAR associated with agonist
15) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.18
can interfere with PPAR activity, and other nuclear receptors, by competing for coactivators [8].
Negative_regulation (interfere) of PPAR
16) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.12 Pain Relevance 0
repressed PPAR?
Negative_regulation (repressed) of PPAR
17) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.16 Pain Relevance 0
The periovulatory expression pattern of PPAR?
Negative_regulation (pattern) of PPAR
18) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.16 Pain Relevance 0.05
In both granulosa [78] and liver cells [82], agonists of PPAR?
Negative_regulation (agonists) of PPAR in liver associated with agonist
19) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.05 Pain Relevance 0.17
In human chondrocytes, the inhibitory potency of 15d-PGJ2 was similar to our results on PGE2 levels [51], although supported by a stronger inhibition of COX-2 and a PPAR?
Negative_regulation (inhibition) of PPAR in chondrocytes associated with potency
20) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.23 Pain Relevance 0.28

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