INT170939

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 19
Disease Relevance 4.59
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Lpo) cellular_component (Lpo) biological_process (Lpo)
Anatomy Link Frequency
striatum 1
Lpo (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 90 99.12 Very High Very High Very High
Nicotine 13 63.24 Quite High
Dopamine 24 5.00 Very Low Very Low Very Low
Substantia nigra 24 5.00 Very Low Very Low Very Low
anesthesia 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 218 99.68 Very High Very High Very High
Urological Neuroanatomy 42 97.84 Very High Very High Very High
Nicotine Addiction 65 97.64 Very High Very High Very High
Genetic Predisposition To Disease 13 75.64 Quite High
Disease 71 73.64 Quite High
Parkinson's Disease 24 69.64 Quite High
Cancer 26 50.28 Quite High
Sprains And Strains 18 39.36 Quite Low
Increased Venous Pressure Under Development 13 9.16 Low Low
Pulmonary Disease 13 8.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the rate of increase of LPO in case of AT + smoked animals were comparatively less.
Positive_regulation (increase) of LPO
1) Confidence 0.65 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.29 Pain Relevance 0
However, AT appears to be responsible for the retarded increase of LPO in the AT + smoked group with increase in the duration of smoking.
Positive_regulation (increase) of LPO associated with nicotine addiction
2) Confidence 0.65 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.30 Pain Relevance 0
As the exposure of CS to the mice was extended from 2 to 4, 6 and 8 weeks, a significant increase in the LPO levels was observed.
Positive_regulation (increase) of LPO
3) Confidence 0.65 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.39 Pain Relevance 0
The level of LPO after a single ip dose (10 mg/kg) was increased in as short a time as 1 hr (although not significantly) and persisted for up to 28 days.
Positive_regulation (increased) of LPO
4) Confidence 0.61 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2022643 Disease Relevance 0.06 Pain Relevance 0.12
Multiple doses of PQ significantly increased the level of LPO in each region (region ANOVAs: VM, F3,12 = 9.9, p = 0.001; STR, F3,12 =17.9, p < 0.0001; FCtx, F3,12 = 3.8, p = 0.04) when measured after 1 week compared with saline.
Positive_regulation (increased) of LPO associated with urological neuroanatomy and midbrain
5) Confidence 0.61 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2022643 Disease Relevance 0.19 Pain Relevance 0.15
However, the extent of the increase in the pulmonary LPO levels in the AT + smoked group was comparatively low as compared to the animals not fed with AT and only exposed to CS.
Positive_regulation (increase) of LPO
6) Confidence 0.57 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.38 Pain Relevance 0
Therefore, the depletion of GSH seems to be associated with the increase of LPO.
Positive_regulation (increase) of LPO
7) Confidence 0.57 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.21 Pain Relevance 0
It seems that the treatment of CS inhalation for 2 weeks was not enough to pose any significant oxidative stress and thereby no increase in LPO.
Neg (no) Positive_regulation (increase) of LPO associated with stress
8) Confidence 0.57 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.54 Pain Relevance 0.03
Interestingly, repeated dosing did not result in an increase in the amount of LPO (Figure 4B).
Positive_regulation (increase) of LPO
9) Confidence 0.53 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2022643 Disease Relevance 0.18 Pain Relevance 0.16
Younes and Siegers [11] have also observed that depletion of GSH enhances LPO.
Positive_regulation (enhances) of LPO
10) Confidence 0.47 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.27 Pain Relevance 0
However, the extent of increase in LPO levels due to CS exposure for 4, 6 or 8 weeks in the mice treated with AT was comparatively less.
Positive_regulation (increase) of LPO
11) Confidence 0.44 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC60661 Disease Relevance 0.12 Pain Relevance 0
It was also observed that as the exposure to CS was extended from 4 to 6 and then to 8 weeks, there was a corresponding increase in the pulmonary LPO levels in both, the smoked as well as the AT + smoked group.
Positive_regulation (increase) of LPO
12) Confidence 0.44 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.28 Pain Relevance 0
In our studies, a significant decrease in the GSH levels was observed in both the smoked as well as AT + smoked groups and concomitantly there was an increase in the LPO levels.
Positive_regulation (increase) of LPO
13) Confidence 0.44 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.21 Pain Relevance 0
There was a gradual increase in the LPO levels as the extent of CS inhalation increased from 4 to 8 weeks.
Positive_regulation (increase) of LPO
14) Confidence 0.44 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC60661 Disease Relevance 0.12 Pain Relevance 0
However, the extent of increase in LPO levels was comparatively less in the AT + smoked group.
Positive_regulation (increase) of LPO
15) Confidence 0.41 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.06 Pain Relevance 0
Despite the cumulative tissue levels of PQ after one, three, and five doses, the level of LPO was not further increased.
Neg (not) Positive_regulation (increased) of LPO
16) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC2022643 Disease Relevance 0.24 Pain Relevance 0.17
An elevated level of LPO was still present in VM after 28 days.
Positive_regulation (elevated) of LPO associated with midbrain
17) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC2022643 Disease Relevance 0.26 Pain Relevance 0.18
In this phase of study it was observed that CS inhalation triggered LPO both in smoked and AT + smoked group.
Positive_regulation (triggered) of LPO
18) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.21 Pain Relevance 0
The level of tissue lipid peroxides (LPO) was differentially elevated in three regions, being highest in VM, lower in striatum (STR), and least in frontal cortex (FCtx), with the earliest significant elevation detected at 1 day.
Positive_regulation (elevated) of LPO in striatum associated with urological neuroanatomy and midbrain
19) Confidence 0.35 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC2022643 Disease Relevance 0.26 Pain Relevance 0.18

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