INT17094

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Context Info
Confidence 0.41
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.82
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC25A4) generation of precursor metabolites and energy (SLC25A4) mitochondrion (SLC25A4)
small molecule metabolic process (SLC25A4) enzyme binding (SLC25A4) transmembrane transport (SLC25A4)
SLC25A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 16 99.92 Very High Very High Very High
adenocard 1 76.72 Quite High
peripheral neuropathy 8 70.32 Quite High
Multiple sclerosis 10 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Electroencephalography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infarction 10 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 8 100.00 Very High Very High Very High
Cv General 3 Under Development 16 99.92 Very High Very High Very High
Disease 22 85.32 High High
Syndrome 6 79.20 Quite High
Coronary Artery Disease 2 75.00 Quite High
Liver Failure 1 74.48 Quite High
Epilepsy 1 72.88 Quite High
Ataxia 11 70.96 Quite High
Peripheral Neuropathy 8 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The systolic peak flow velocity (PFVs) was significantly reduced only in INF + POS compared with those in ANT, EAP and VAP (36.8 +/- 1.8 cm/sec vs 46.9 +/- 2.1 cm/sec, 46.4 +/- 2.1 cm/sec and 42.6 +/- 1.9 cm/sec, p less than 0.05, respectively).
Negative_regulation (reduced) of ANT associated with angina, polycystic ovary syndrome and infarction
1) Confidence 0.41 Published 1991 Journal Jpn. Circ. J. Section Abstract Doc Link 1875525 Disease Relevance 1.62 Pain Relevance 0.73
PFVs/PFVd was significantly reduced only in INF + POS compared with those in ANT, EAP, and VAP (1.39 +/- 0.05 vs. 1.75 +/- 0.08, 1.76 +/- 0.09, and 1.62 +/- 0.09, p less than 0.05, respectively).
Negative_regulation (reduced) of ANT associated with angina, polycystic ovary syndrome and infarction
2) Confidence 0.41 Published 1991 Journal Jpn. Circ. J. Section Abstract Doc Link 1875525 Disease Relevance 1.56 Pain Relevance 0.72
Over the past decade, a growing number of nuclear genetic defects have been identified that disrupt mitochondrial function either by a reduction in mtDNA copy number, and/or the accumulation of secondary mtDNA deletions: POLG1, POLG2, PEO1, SLC25A4, TYMP, DGUOK, TK2, SUCLA2, SUCLG1, MPV17 and RRM2B (Hudson and Chinnery, 2006; Chinnery and Zeviani, 2008; Copeland, 2008).
Negative_regulation (reduction) of SLC25A4
3) Confidence 0.17 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.64 Pain Relevance 0.07

General Comments

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