INT170979

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.08
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL5) extracellular region (IL5)
Anatomy Link Frequency
internal 1
IL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 255 100.00 Very High Very High Very High
cytokine 154 100.00 Very High Very High Very High
chemokine 42 100.00 Very High Very High Very High
dexamethasone 45 94.12 High High
agonist 27 76.04 Quite High
fibrosis 7 73.04 Quite High
Inflammatory response 10 68.04 Quite High
Potency 4 10.40 Low Low
antagonist 35 5.00 Very Low Very Low Very Low
corticosteroid 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 272 100.00 Very High Very High Very High
Eosinophilia 49 99.60 Very High Very High Very High
Asthma 519 99.18 Very High Very High Very High
Disease 64 98.38 Very High Very High Very High
Nicotine Addiction 8 95.68 Very High Very High Very High
Ocular Hypertension 7 91.92 High High
Recurrence 1 87.00 High High
Adhesions 13 83.84 Quite High
Metaplasia 6 75.44 Quite High
Glaucoma 2 73.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticoids, the most effective agents for reducing eosinophilia, suppress the gene transcription of IL-3, IL-4, IL-5, GM-CSF, and various chemokines [1].
Transcription (transcription) of IL-5 associated with chemokine and eosinophilia
1) Confidence 0.33 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.54 Pain Relevance 0.10
B, but this does not account for all effects, as IL-10 is very effective at inhibiting IL-5 transcription, which is independent of NF-?
Transcription (transcription) of IL-5
2) Confidence 0.13 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.02 Pain Relevance 0.28
In maternal data all markers remained statistically significant after adjustments, with the exception of FV rs9332624, IL-5 rs739718, and PTGER3 rs977214.
Neg (exception) Transcription (exception) of IL-5
3) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.10 Pain Relevance 0
In fact, greater number of activated eosinophils was seen in the airways <2 mm internal diameter than in the airways >2 mm internal diameter, suggesting that similar but more severe inflammatory process is present in the distal airways.[26] In the same cohort of patients, we have also shown increased IL-5 and IL-4 mRNA-positive cells in the distal airways of asthmatic subjects compared to non-asthmatic controls,[12] and more importantly, the expression of IL-5 mRNA was increased in the distal airways compared to the large airways.[12] Numbers of cells expressing IL-2 and IFN-?
Transcription (expression) of IL-5 in internal associated with asthma and inflammation
4) Confidence 0.07 Published 2007 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2732069 Disease Relevance 0.92 Pain Relevance 0.11
Although the glucocorticoid action in inflammatory diseases is not fully understood, it is well documented that glucocorticoids inhibit the transcription of the majority of inflammatory cytokines and chemokines involved in the inflammatory process, including eotaxin, GM-CSF, IL-1ß, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-11, MCP-1, MIP-1, MIP-3, MIP-4, MIP-1?
Transcription (transcription) of IL-5 associated with chemokine, inflammation, disease and cytokine
5) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.28 Pain Relevance 0.56
More importantly, the expression of IL-5 mRNA was increased in the small airways compared with the large airways (Fig. 4) [5].
Transcription (expression) of IL-5
6) Confidence 0.05 Published 2001 Journal Respir Res Section Body Doc Link PMC64806 Disease Relevance 0.56 Pain Relevance 0.08
In the same cohort of patients, we also showed increased IL-5 and IL-4 mRNA-positive cells in the small airways of asthmatic persons as compared with nonasthmatic control individuals (Fig. 4) [5].
Transcription (showed) of IL-5 associated with asthma
7) Confidence 0.04 Published 2001 Journal Respir Res Section Body Doc Link PMC64806 Disease Relevance 0.66 Pain Relevance 0.08

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