INT170987

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 2.71
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
chondrocytes 2
osteoblasts 1
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 457 99.14 Very High Very High Very High
Inflammatory response 17 87.28 High High
Inflammatory mediators 8 82.00 Quite High
Arthritis 16 74.80 Quite High
antagonist 4 69.04 Quite High
Pain 10 63.76 Quite High
Inflammation 145 60.88 Quite High
cINOD 26 59.60 Quite High
agonist 4 40.04 Quite Low
COX-2 inhibitor 19 34.72 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 490 99.14 Very High Very High Very High
INFLAMMATION 190 87.28 High High
Osteophyte 10 79.32 Quite High
Arthritis 16 74.80 Quite High
Pain 10 63.76 Quite High
Osteoporosis 5 44.80 Quite Low
Asthma 6 21.92 Low Low
Disease 50 20.52 Low Low
Infection 2 11.40 Low Low
Necrosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insertions or deletions within the promoter region for this gene, which encodes recognition sites for the transcription factor SP1, alter the level of transcription of the 5-lipoxygenase gene and hence the 5-lipoxygenase activity present within tissue [26,27,28].
Transcription (transcription) of 5-lipoxygenase
1) Confidence 0.69 Published 2002 Journal Respir Res Section Body Doc Link PMC64808 Disease Relevance 0 Pain Relevance 0.03
Insertions or deletions within the promoter region for this gene, which encodes recognition sites for the transcription factor SP1, alter the level of transcription of the 5-lipoxygenase gene and hence the 5-lipoxygenase activity present within tissue [26,27,28].
Transcription (transcription) of 5-lipoxygenase
2) Confidence 0.67 Published 2002 Journal Respir Res Section Body Doc Link PMC64808 Disease Relevance 0 Pain Relevance 0.03
As shown in Figure 4b, c, our data disclosed that both FLAP and 5-LOX mRNA expression rose significantly but differentially after incubation in human OA chondrocytes.
Transcription (expression) of 5-LOX in chondrocytes associated with osteoarthritis
3) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.37 Pain Relevance 0.18
These data indicate that HNE regulates 5-LOX mRNA expression at the transcriptional level.


Transcription (expression) of 5-LOX
4) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.29 Pain Relevance 0.14
The combination of naproxen with HNE, however, had no additive effect on 5-LOX mRNA expression.
Transcription (expression) of 5-LOX
5) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.52 Pain Relevance 0.32
HNE-induced 5-LOX promoter activity
Transcription (activity) of 5-LOX
6) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.26 Pain Relevance 0.13
Heightened LTB4 production upon HNE stimulation occurred 48 hours after the beginning of stimulation, coinciding with the time at which the 5-LOX mRNA level was elevated, and FLAP gene expression remained high.
Transcription (level) of 5-LOX
7) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0
The addition of naproxen to HNE had no additive effect on the 5-LOX mRNA level.
Transcription (level) of 5-LOX
8) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.06 Pain Relevance 0.03
To more accurately identify whether HNE induced 5-LOX at the transcription level, the 5-LOX promoter construct with luciferase gene reporter was transiently transfected into human OA chondrocytes, followed by stimulation with single addition of 10 ?
Transcription (transcription) of 5-LOX in chondrocytes associated with osteoarthritis
9) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.27 Pain Relevance 0.13
Incubation of cells with naproxen, however, caused a consistent increase of 5-LOX mRNA level by 330% and 570% of control values (P < 0.001) after 24 and 72 hours of incubation, respectively (Figure 6c, d).
Transcription (level) of 5-LOX
10) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.07 Pain Relevance 0.03
FLAP mRNA levels varied in low and high OA groups compared with normal, whereas mRNA levels of 5-LO were similar in all osteoblasts.
Transcription (levels) of 5-LO in osteoblasts associated with osteoarthritis
11) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794527 Disease Relevance 0.88 Pain Relevance 0.36

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