INT170989

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Context Info
Confidence 0.26
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.58
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 88 91.48 High High
Inflammatory response 4 87.28 High High
Inflammatory mediators 2 82.00 Quite High
Arthritis 4 74.80 Quite High
antagonist 2 66.32 Quite High
Pain 2 63.76 Quite High
cINOD 5 59.60 Quite High
agonist 2 40.80 Quite Low
COX-2 inhibitor 4 34.72 Quite Low
aspirin 1 20.64 Low Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 91.48 High High
INFLAMMATION 47 87.28 High High
Arthritis 4 74.80 Quite High
Pain 2 63.76 Quite High
Disease 18 21.28 Low Low
Asthma 3 19.20 Low Low
Infection 1 12.16 Low Low
Respiratory Disease 3 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insertions or deletions within the promoter region for this gene, which encodes recognition sites for the transcription factor SP1, alter the level of transcription of the 5-lipoxygenase gene and hence the 5-lipoxygenase activity present within tissue [26,27,28].
Regulation (alter) of Transcription (transcription) of 5-lipoxygenase
1) Confidence 0.26 Published 2002 Journal Respir Res Section Body Doc Link PMC64808 Disease Relevance 0 Pain Relevance 0.03
The addition of naproxen to HNE had no additive effect on the 5-LOX mRNA level.
Neg (no) Regulation (effect) of Transcription (level) of 5-LOX
2) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.06 Pain Relevance 0.03
The combination of naproxen with HNE, however, had no additive effect on 5-LOX mRNA expression.
Neg (no) Regulation (effect) of Transcription (expression) of 5-LOX
3) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.52 Pain Relevance 0.32

General Comments

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