INT170992

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.13
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FN1, MMRN1) cell adhesion (FN1, MMRN1) extracellular space (FN1)
proteinaceous extracellular matrix (FN1)
Anatomy Link Frequency
chondrocyte 1
mesenchymal cells 1
FN1 (Homo sapiens)
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 4 99.24 Very High Very High Very High
Kinase C 1 95.24 Very High Very High Very High
Osteoarthritis 53 85.36 High High
metalloproteinase 17 84.36 Quite High
Catecholamine 1 79.04 Quite High
agonist 3 74.64 Quite High
Tendonitis 1 68.32 Quite High
cytokine 54 57.76 Quite High
Inflammation 106 50.44 Quite High
dexamethasone 7 39.36 Quite Low
Disease Link Frequency Relevance Heat
Fibrosis 5 99.24 Very High Very High Very High
Asthma 41 95.72 Very High Very High Very High
Injury 20 91.60 High High
Adhesions 13 90.00 High High
Airway Remodeling 13 86.84 High High
Knee Osteoarthritis 36 85.36 High High
Infection 2 70.08 Quite High
Pseudarthrosis 1 70.04 Quite High
Necrosis 18 69.24 Quite High
Tendinopathy 1 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is an extremely potent stimulus for the synthesis of ECM components such as collagen and fibronectin leading to tissue fibrosis and it can also inhibit ASM NO production, potentially resulting in a loss of control of airway calibre.
fibronectin Binding (collagen) of ECM associated with fibrosis
1) Confidence 0.01 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.66 Pain Relevance 0.15
These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [4].
fibronectin Binding (interact) of ECM in chondrocyte
2) Confidence 0.00 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 1.11 Pain Relevance 0.53
At this stage, the undifferentiated mesenchymal cells produce an ECM enriched with collagen type I, hyaluronan, tenascin and fibronectin.
fibronectin Binding (enriched) of ECM in mesenchymal cells
3) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.36 Pain Relevance 0.05

General Comments

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