INT1710

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Context Info
Confidence 0.37
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 3.85
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Etn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 47 100.00 Very High Very High Very High
Etanercept 41 100.00 Very High Very High Very High
Enkephalin 8 99.04 Very High Very High Very High
spinal inflammation 50 85.44 High High
antagonist 49 76.96 Quite High
Arthritis 58 50.00 Quite Low
Adalimumab 40 50.00 Quite Low
depression 11 36.16 Quite Low
Hippocampus 22 5.00 Very Low Very Low Very Low
Opioid 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 1166 98.88 Very High Very High Very High
Low Back Pain 57 85.44 High High
Disease Susceptibility 11 65.80 Quite High
Cancer 48 59.44 Quite High
Malignant Neoplastic Disease 11 56.20 Quite High
Disease 24 56.12 Quite High
Seronegative Spondarthritis 54 50.00 Quite Low
Necrosis 4 50.00 Quite Low
Congenital Anomalies 33 48.88 Quite Low
Depression 11 36.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sense-oriented ETn element found in the Dysf gene in A/J has already been shown to cause similar splicing defects [38] and we did not examine A2bp1.
Gene_expression (found) of ETn element
1) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0 Pain Relevance 0
Prevalence of ETn/MusDs and IAPs in Different Strains
Gene_expression (/) of ETn associated with sprains and strains
2) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.49 Pain Relevance 0
Indeed, of the 19 cases of ETn elements known to disrupt gene expression in various new mutations, 16 are oriented in the same direction as the gene [8],[32], indicating that sense-oriented elements are much more likely to perturb gene expression, causing a detectable phenotype, and being subject to negative selection.
Gene_expression (expression) of ETn
3) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.12 Pain Relevance 0
By comparing only the few strains for which sufficient genomic sequence is available, we found high levels of insertional polymorphism for both the IAP and ETn/MusD families.
Gene_expression (families) of ETn associated with sprains and strains
4) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.47 Pain Relevance 0
To capture ETnI elements, which differ from ETnII/MusD elements in the 3?
Gene_expression (elements) of ETnII
5) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.05 Pain Relevance 0
Among the polymorphic copies, 623 IAPs and 72 ETn/MusD elements reside in gene introns.
Gene_expression (reside) of ETn
6) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.35 Pain Relevance 0
As discussed above, our genomic survey detected 1873 MusD/ETn elements and 5072 IAPs in assembled B6 genome.
Gene_expression (detected) of ETn
7) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.45 Pain Relevance 0
One of these cases was #24 in Table 1, where we predicted an ETn/MusD insertion in an intron of the Sytl3 gene in A/J mice.
Gene_expression (insertion) of ETn
8) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.34 Pain Relevance 0
Thus, throughout this study, this group is referred to as ETn/MusD elements.
Gene_expression (elements) of ETn
9) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.41 Pain Relevance 0
For the 28 cases of elements computationally detected in A/J (cases 1–28 in Table 1), the ETn insertion in the dysferlin (Dysf ) gene (case #9) is the only previously reported case and occurred 20–30 years ago in the A/J breeding stocks [38].
Gene_expression (insertion) of ETn
10) Confidence 0.33 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.49 Pain Relevance 0
In all five cases of sense-oriented ETn elements in A/J introns that we examined, evidence for gene splicing disruption was found by RT-PCR and, for two genes, further evidence of lower gene expression in A/J mice was observed through surveys of microarray data.
Gene_expression (elements) of ETn
11) Confidence 0.33 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.33 Pain Relevance 0
An arylazide enkephalin derivative, [D-Ala2,Met5]enkephalin-Tyr-N-(2-nitro-4-azidophenyl) ethylenediamine (ETN), has been synthesized.
Gene_expression (synthesized) of ETN associated with enkephalin
12) Confidence 0.02 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 227880 Disease Relevance 0 Pain Relevance 0.58
In the logistic regression, the odds of achieving an ASAS40 response were not statistically different (P = 0.083) for patients with only prior IFX therapy or only ETN therapy, compared with the reference group of patients who had received both IFX and ETN (Table 5).
Gene_expression (received) of ETN associated with infliximab and etanercept
13) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911911 Disease Relevance 0.34 Pain Relevance 0.81

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