INT17101

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 24
Total Number 29
Disease Relevance 24.90
Pain Relevance 8.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
myocardium 4
brain 4
cardiac myocytes 2
tail 2
thoracic 2
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 106 99.76 Very High Very High Very High
tail-flick 2 99.12 Very High Very High Very High
Morphine 5 99.04 Very High Very High Very High
antagonist 41 98.86 Very High Very High Very High
intrathecal 2 98.36 Very High Very High Very High
Intracerebroventricular 2 97.88 Very High Very High Very High
Bioavailability 6 97.54 Very High Very High Very High
withdrawal 4 94.44 High High
fibrosis 120 93.00 High High
Antinociceptive 5 92.48 High High
Disease Link Frequency Relevance Heat
Cancer 37 99.98 Very High Very High Very High
Thrombosis 33 99.90 Very High Very High Very High
Disease 395 99.80 Very High Very High Very High
Pain 83 99.76 Very High Very High Very High
Reprotox - General 1 23 99.72 Very High Very High Very High
Diabetes Mellitus 52 99.56 Very High Very High Very High
Adhesions 56 99.52 Very High Very High Very High
Stress 62 99.42 Very High Very High Very High
Fibrosis 126 99.40 Very High Very High Very High
Increased Venous Pressure Under Development 48 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In some diseases in which endothelin-1 (ET-1) production increases (e.g. prostate cancer), ET-1 is considered to be involved in the generation of pain.
Positive_regulation (increases) of Gene_expression (production) of ET-1 associated with pain, disease and reprotox - general 1
1) Confidence 0.69 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838353 Disease Relevance 1.07 Pain Relevance 0.52
In some diseases in which endothelin-1 production increases, e.g. prostate cancer, endothelin-1 is considered to be involved in the generation of pain.
Positive_regulation (increases) of Gene_expression (production) of endothelin-1 associated with pain, disease and reprotox - general 1
2) Confidence 0.68 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178362 Disease Relevance 0.82 Pain Relevance 0.37
These results suggest that selective endothelin ET(A) receptor antagonists might relieve pain in patients with various diseases in which endothelin-1 production is increased, e.g. prostate cancer.
Positive_regulation (increased) of Gene_expression (production) of endothelin-1 associated with pain, antagonist, disease and reprotox - general 1
3) Confidence 0.68 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178362 Disease Relevance 1.40 Pain Relevance 0.67
Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect.
Positive_regulation (upregulated) of Gene_expression (expression) of ET-1 protein associated with cancer, antagonist, antinociceptive and withdrawal
4) Confidence 0.67 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16807013 Disease Relevance 0.96 Pain Relevance 0.60
Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection of endothelin-1 (ET-1; 0.1 mg/kg).
Positive_regulation (induced) of Gene_expression (injection) of endothelin-1 associated with intracerebroventricular, morphine and intrathecal
5) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1875787 Disease Relevance 0.19 Pain Relevance 0.50
Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection of endothelin-1 (ET-1; 0.1 mg/kg).
Positive_regulation (induced) of Gene_expression (injection) of ET-1 associated with intracerebroventricular, morphine and intrathecal
6) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1875787 Disease Relevance 0.19 Pain Relevance 0.50
In some diseases in which endothelin-1 (ET-1) production increases (e.g. prostate cancer), ET-1 is considered to be involved in the generation of pain.
Positive_regulation (increases) of Gene_expression (production) of endothelin-1 associated with pain, disease and reprotox - general 1
7) Confidence 0.50 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838353 Disease Relevance 1.07 Pain Relevance 0.52
These results suggest that selective endothelin-A receptor antagonists relieve pain in patients with various diseases in which ET-1 production increases (e.g. prostate cancer).
Positive_regulation (increases) of Gene_expression (production) of ET-1 associated with pain, antagonist, disease and reprotox - general 1
8) Confidence 0.50 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838353 Disease Relevance 1.67 Pain Relevance 0.72
ET-1 (0.625-5 pmol/mouse) and ET-3 (2.5-25 pmol/mouse) produced statistically significant increase of the hot plate and tail flick latencies with duration of about 120 min.
Positive_regulation (increase) of Gene_expression (produced) of ET-1 in tail associated with tail-flick
9) Confidence 0.49 Published 1993 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8255123 Disease Relevance 0 Pain Relevance 0.41
Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect.
Positive_regulation (upregulated) of Gene_expression (expression) of ET-1 associated with cancer, antagonist, antinociceptive and withdrawal
10) Confidence 0.48 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16807013 Disease Relevance 0.96 Pain Relevance 0.60
Similar to fibrosarcomas, MPNST's were also found to have nearly 3-fold increased expression of the ET-1 gene compared to normal schwann cells [20], suggesting that ET-1 upregulation may be a consistent feature of sarcomas in general, and raising the possibility that ET-1 antagonism might be useful in treating MPNST rest pain, though formal in vivo evidence is presently lacking.
Positive_regulation (increased) of Gene_expression (expression) of ET-1 in schwann cells associated with pain, sarcoma, nerve sheath neoplasms and fibrosarcoma
11) Confidence 0.44 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2291052 Disease Relevance 1.57 Pain Relevance 0.82
In contrast with our findings that ET-1 induced primarily an increase in Raw, with a smaller increase in G and no change in H in the control mice, Nagase et al. observed similar increases in the airway and parenchymal mechanical parameters at all ET-1 doses administered iv to naive animals.
Positive_regulation (increase) of Neg (no) Gene_expression (induced) of ET-1
12) Confidence 0.44 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.13 Pain Relevance 0
In contrast with our findings that ET-1 induced primarily an increase in Raw, with a smaller increase in G and no change in H in the control mice, Nagase et al. observed similar increases in the airway and parenchymal mechanical parameters at all ET-1 doses administered iv to naive animals.
Positive_regulation (increase) of Neg (no) Gene_expression (induced) of ET-1
13) Confidence 0.44 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.13 Pain Relevance 0
CONCLUSIONS: In patients without organic heart disease, plasma ET-1 levels do not increase in response to major abdominal or thoracic surgery.
Neg (not) Positive_regulation (increase) of Gene_expression (levels) of ET-1 in thoracic
14) Confidence 0.42 Published 2000 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 10794331 Disease Relevance 0 Pain Relevance 0
The OVA challenge-induced IFN-gamma and ET-1 productions were inhibited in IL-18(-/-) immunized mice, as well as ET-1 production in IFN-gamma(-/-) immunized mice.
Positive_regulation (challenge-induced) of Gene_expression (productions) of ET-1
15) Confidence 0.35 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.27 Pain Relevance 0.39
In addition, significant PGE2 production was detected after IL-18 or ET-1 (via ET(A) receptors) injection in naïve mice.
Positive_regulation (detected) of Gene_expression (injection) of ET-1
16) Confidence 0.35 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.28 Pain Relevance 0.39
However, neuron-specific EDN1-knockout mice show elevated sensitivity to pain [100], and EDN1 expression in astrocytes is required for their survival under oxidative stress [101].
Positive_regulation (required) of Gene_expression (expression) of EDN1 in neuron associated with stress, targeted disruption and pain
17) Confidence 0.31 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.45 Pain Relevance 0.35
In addition, increased production of ET-1 by cardiac myocytes correlates closely with the degree of hemodynamic and functional impairment [76], [115], indicating that this peptide could also contribute to myocardial fibrosis through its collagen synthesis-enhancing effect [116].


Positive_regulation (increased) of Gene_expression (production) of ET-1 in cardiac myocytes associated with fibrosis
18) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 0.65 Pain Relevance 0.23
Increased production of ET-1 may contribute to the coronary microvascular vasoconstriction previously reported in experimental Chagas disease [9].


Positive_regulation (Increased) of Gene_expression (production) of ET-1 associated with american trypanosomiasis and increased venous pressure under development
19) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 0.79 Pain Relevance 0.04
It has been hypothesized that T. cruzi–derived molecules provoke overexpression of ET-1 [77].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ET-1
20) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 1.25 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox