INT171019

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Context Info
Confidence 0.27
First Reported 2002
Last Reported 2007
Negated 3
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 12.08
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SMPD1) extracellular space (SMPD1) small molecule metabolic process (SMPD1)
hydrolase activity, acting on glycosyl bonds (SMPD1) cell death (SMPD1)
Anatomy Link Frequency
T lymphocytes 2
macrophage 1
endothelial cell 1
endothelium 1
SMPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 416 99.98 Very High Very High Very High
chemokine 194 99.98 Very High Very High Very High
fibrosis 12 99.50 Very High Very High Very High
Inflammation 788 99.34 Very High Very High Very High
Kinase C 290 98.84 Very High Very High Very High
amygdala 22 97.52 Very High Very High Very High
agonist 936 97.12 Very High Very High Very High
Inflammatory response 52 91.68 High High
adenocard 132 91.48 High High
bradykinin 174 91.44 High High
Disease Link Frequency Relevance Heat
Bronchopulmonary Dysplasia 12 100.00 Very High Very High Very High
Personality Disorder 15 99.90 Very High Very High Very High
Borderline Personality 1 99.84 Very High Very High Very High
Hyperplasia 24 99.76 Very High Very High Very High
Fibrosis 18 99.50 Very High Very High Very High
Asthma 934 99.40 Very High Very High Very High
INFLAMMATION 936 99.34 Very High Very High Very High
Adhesions 74 99.18 Very High Very High Very High
Airway Remodeling 110 98.80 Very High Very High Very High
Influenza Virus Infection 6 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
StAR, SULT2A1, HSD17B4, AKR1C4 and CYP11A1 were all differentially expressed in both D and NL (p < 0.01), while SMPD1 was not significantly differentially expressed in either of the two breeds (Table 4 and 5, respectively).


Neg (not) Gene_expression (expressed) of SMPD1
1) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2204014 Disease Relevance 0 Pain Relevance 0
In some cases the evidence for their expression in ASM is either indirect or is difficult to interpret given the labile nature of Gq-coupled receptor expression in ASM cultures.
Gene_expression (expression) of ASM
2) Confidence 0.12 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.19
2AR signaling in ASM, in light of findings by McGraw et al. suggesting that low (endogenous) expression levels of GRKs in ASM cells account for relatively robust ?
Gene_expression (signaling) of ASM
3) Confidence 0.12 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.43 Pain Relevance 0.23
Accordingly, it is no longer permissible to judge the relevance of a given ASM GPCR based on its ability to dynamically modulate ASM contractile state and airway resistance.
Gene_expression (based) of ASM
4) Confidence 0.12 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.38 Pain Relevance 0.17
Recent findings demonstrate that GPCR-mediated contraction of ASM strips ex vivo is augmented by various "sensitization" strategies [165].
Gene_expression (contraction) of ASM
5) Confidence 0.12 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.26 Pain Relevance 0.23
It is an extremely potent stimulus for the synthesis of ECM components such as collagen and fibronectin leading to tissue fibrosis and it can also inhibit ASM NO production, potentially resulting in a loss of control of airway calibre.
Neg (NO) Gene_expression (production) of ASM associated with fibrosis
6) Confidence 0.11 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.59 Pain Relevance 0.13
Chemokine production by human ASM
Gene_expression (production) of ASM associated with chemokine
7) Confidence 0.11 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.85 Pain Relevance 0.39
Cytokine production by human ASM
Gene_expression (production) of ASM associated with cytokine
8) Confidence 0.11 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.10 Pain Relevance 0.67
Consequences for ASM physiology
Gene_expression (physiology) of ASM
9) Confidence 0.11 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.59 Pain Relevance 0.49
Figure 5 offers a model that proposes 3 levels at which regulation of GPCR-mediated ASM contraction is altered in asthma.
Gene_expression (contraction) of ASM associated with asthma
10) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.48 Pain Relevance 0.14
Interestingly, AC subtype expression in ASM cultures may be species specific, as regulatory features of AC in bovine, canine, and guinea pig ASM suggest prominent expression of AC II [48-51], whereas a minimal [46] or no [47] level of AC II transcripts were detected in human ASM (see below).
Gene_expression (expression) of ASM
11) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0
Models for analyzing GPCR signaling in ASM
Gene_expression (signaling) of ASM
12) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.35 Pain Relevance 0.12
Interestingly, AC subtype expression in ASM cultures may be species specific, as regulatory features of AC in bovine, canine, and guinea pig ASM suggest prominent expression of AC II [48-51], whereas a minimal [46] or no [47] level of AC II transcripts were detected in human ASM (see below).
Neg (no) Gene_expression (detected) of ASM
13) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0
Conversely, glucocorticoids inhibit expression of NK2 receptors in bovine ASM [94], inhibit m2 mAChR expression in the airway [200], and inhibit the IL-1?
Gene_expression (expression) of ASM
14) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.48 Pain Relevance 0.32
Both thrombin (capable of activating Gq through protease-activated receptors (PARs) [34]) and lysophosphatidic acid (LPA) (capable of activating Gq through endothelium differentiation gene (EDG) receptors) are strong stimulators of cultured ASM DNA synthesis and cell proliferation.
Gene_expression (synthesis) of ASM in endothelium
15) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.14
2AR signaling in ASM [186], and that such signaling may be sensitive to changes in GRK [72] or arrestin [20] expression.
Gene_expression (signaling) of ASM
16) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.48 Pain Relevance 0.21
A diagram of Gq-coupled receptor signaling, and the associated functional outcomes in ASM, is provided in Fig. 1.
Gene_expression (diagram) of ASM
17) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.08 Pain Relevance 0.07
i family expressed in ASM include G?
Gene_expression (expressed) of ASM
18) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.07 Pain Relevance 0.08
Thus, the profile of AC transcripts and regulatory features of AC in human ASM suggest a predominance of AC VI or V in human ASM, whereas PKC-sensitive isoforms, perhaps AC II, may be preferentially expressed in non-human ASM.



Gene_expression (expressed) of ASM associated with kinase c
19) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.39 Pain Relevance 0.33
2AR function in the airway through both their anti-inflammatory actions as well as their direct effects on ASM ?
Gene_expression (effects) of ASM associated with inflammation
20) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.18 Pain Relevance 0.31

General Comments

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